Kardea Nutrition-Heart Healthy & Inspired

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2010-04-30T10:09:00.001-04:00

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Cholesterol Drugs Increase Risk of Diabetes; Diabetes Drugs Increase Risk of Heart Attacks

2010-02-22T09:39:00.003-05:00

In the age of medical specialists, we can find ourselves being treated as a collection of conditions. Our whole health can get lost. You may find yourselves taking a variety of medications, perhaps one for cholesterol, another for high blood pressure and yet another to regulate blood glucose levels. These medications each may be appropriate, but they also may works against each other.
Two studies regarding cholesterol lowering medications and a diabetes drugs are cases in point.

Lipitor, Crestor and other statin medications taken to lower cholesterol also increase the risk of diabetes, by about a 9 percent, according to a study that quantified a complication that doctors only recently discovered.

Meanwhile, hundreds of people taking Avandia, a diabetes medicine, needlessly suffer heart attacks and heart failure each month, according to confidential government reports that recommend the drug be removed from the market.

The statin study analyzed 13 studies undetaken after a 2008 trial from London-based AstraZeneca unexpectedly found patients given its drug Crestor had a 25 percent higher risk of diabetes. The new analysis involving more than 90,000 patients, published in the journal Lancet, shows the actual increase in diabetes is 9 percent, the risk is tied to the entire class of medications and the danger increases with age. As a class, statins are the leading class of drugs sold in the world today, with annual sales exceeding $35 billion.

Avandia, the diabetes medication, was once one of the biggest-selling drugs in the world. Driven in part by a multimillion-dollar advertising campaign, sales were $3.2 billion in 2006. But a 2007 study by a Cleveland Clinic cardiologist suggesting that the drug harmed the heart prompted the F.D.A. to issue a warning, and sales plunged. A committee of independent experts found in 2007 that Avandia might increase the risk of heart attack but recommended that it remain on the market, and an F.D.A. oversight board voted 8 to 7 to accept that advice.

Yes, medications may be approrpriate based on overall risk factors, but they also are powerful chemicals that can negatively effect on our whole health. A solution optimizing the power of nutrition to significantly improve whole health and prevent heart disease can be used in many cases --- either to avoid the intake of medications or significantly reduce the dosages required to achieve target health result. kardea nutrition - heart healthy and inspired - defining statin alternatives. kardea gourmet - great science, fantastic foods and cardiovascular health.

Kardea Nutrition Pledges 10% of Online Sales to Women's Heart Health Campaign

2010-02-04T23:50:00.000-05:00

February 5, 2010. Leading up to the heartiest of holidays (Valentine's 2010), Kardea Nutrition is pledging 10% of sales made through its online store to The American Heart Association Go Red & Give campaign.

Go Red for Women celebrates the energy, passion and power women have by banding together to wipe out heart disease and stroke. Go Red is working hard to change the perception that heart disease is a "man's disease." And it's working! By teaching more and more women how to talk to their doctors about heart disease, Go Red can save thousands of lives every year. The good news is that heart disease is often preventable!

Go-Red-For Women Campaign: American Hearat Association Feb 5-12

2010-02-04T10:36:00.000-05:00

Tomorrow is National Wear Red Day. Thousands of Americans will be wearing red to draw attention to this startling fact: Over 430,000 women are silenced each year by cardiovascular disease – and most of these deaths are preventable.

Kardea encourages you to wear something red tomorrow to honor those women – and that you’ll help fund the research and programs that can save them. Today, the American Heart Associataion is launching a Go Red & Give campaign. One week, one goal: $100,000 to keep our sisters, mothers, daughters and wives safe.

Donate directly to the American Heart Association to support education, outreach and research programs to help save women’s lives.

Your donation could help keep someone you love safe from the #1 killer disease in the U.S.

Kardea Nutrition Teams with The Cooking Cardiologist®

2010-01-27T15:28:00.000-05:00

Kardea Nutrition™ is pleased to announce that it has teamed with Dr Richard Collins, a Mayo Clinic trained cardiologist, also known as The Cooking Cardiologist®, to advance an integrated nutritional approach promoting cardiovascular health and wellness.

“What you eat and how much you eat can significantly alter cardiovascular health,” say Dr. Collins, ”Certain nutrients can be very helpful. Others can be quiet harmful. The power of nutrition lies with the overall eating patterns and preferences.”

The National Institutes of Health and the American Heart Association have long asserted that dietary choices are the foundation of cardiovascular disease prevent and health promotion. The NIH recognizes that lifestyle choices, emphasizing nutrition “compares well with many of the cholesterol-lowering drugs.[i]” For some, food choices allow individuals to maintain healthy cholesterol, blood pressure and blood sugar levels without the use of medications. For others, food choices reduce the medications required to achieve healthy levels.

In addition to serving on Kardea’s Board of Advisors, Dr. Collins will join Kardea’s founder, Robert Leighton, in co-authoring The Kardea Gourmet: Great Science, Fantastic Foods and Cardiovascular Health. This book will provide readers with a clear understanding of how inflammation and cholesterol, blood pressure and blood sugar levels interact to affect cardiovascular health. It then will review the impact of specific nutrients and overall diet. Gourmet chefs from noted restaurants around the country also will be providing the meal plans that deliver the right nutritional balance and heart healthy nutrients including Omega-3s, fibers, plant sterols and antioxidants.

Sections of the book, including recipes, are posted on kardeagourmet.com . Updates are being added on a weekly basis. Kardea is seeking input from interested readers.

Founded in 2007, Kardea Nutrition™ LLC was launched to empower people to manage their cholesterol, naturally and nutritiously. Kardea Nutrition™ has since extended its scope to enable the power of nutrition to advance overall cardiovascular health. It products are currently available at many retailers throughout the United States including Whole Foods , Nordstrom, drugstore.com and Hy-Vee. Products can also be purchased directly from Kardea’s online store.

[1] Your Guide to Lowering Cholesterol with Therapeutic Lifestyle Changes (TLC), U.S. Department of Health and Human Service, National Institutes of Health, National Heart, Lung, and Blood Institute, December 2005. www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf

From Heart Health Claims to Cardiovascular Health Optimizing Nutrition

2010-01-27T08:25:00.001-05:00

Take a stroll through any grocery store, and you may become overwhelmed by the dizzying array of heart healthy products. Cereals, soups, super-fruit drinks, popcorn and chocolate, salad dressings, margarines and oils, yogurts and nutritional bars, pastas and many other food categories have products proclaiming their ability to lower cholesterol and blood pressure, fight inflammation and control blood sugar levels —all factors in the development of cardiovascular diseases. No food or specific nutrient rules in the quest for the healthiest. “Low in sodium,” “low in saturated fat,” “no cholesterol and no trans-fats,” “high in potassium or high antioxidants”, “with plant sterols”, “an excellent source of Omega-3’s ,” and “contains cholesterol lowering fiber” are only some of the pronouncements. Walk over to the vitamin aisle and you will find numerous supplements with similar associations to heart health: CoQ-10, Vitamin E, psyllium, niacin and red yeast rice are just a few.

Many consumers remain dubious. See full article at The Kardea Gourmet.

Kardea Nutrition for Natural Cholesterol Lowering

Lifestyle & Heart Health: Important 2009 Studies

2010-01-06T09:39:00.004-05:00

January 4, 2009 Dallas, TX - The American Heart Association (AHA) chooses important 2009 research papers on heart health and lifestyle choices. One provides insights into obesity prevention and the "best diets." The other cautions that cardiovascular risk-factor control isn't just for older people. A third reviews the significant role of laws restricting smoking in public places to sharply lower the incidence of hospital admissions for heart attacks.

These selections emerged from a process led by the AHA immediate past president, president and president-elect. The choices were based on nominations from the organization's scientific councils. The chairs of the councils had been charged with recommending the year's "most meritorious, most substantial, most significant" papers in cardiovascular medicine, according to AHA current president Dr Clyde W Yancy (Baylor University Medical Center, Dallas, TX). Several of the studies in the final cut, he told heartwire, had been backed by multiple scientific councils.

No Best Diet

In a randomized comparison in more than 800 overweight adults of four "reduced-calorie" dietary interventions consisting of fat, protein, and carbohydrate intake in different proportions, such as 40%, 15%, and 45%, respectively, or 20%, 25%, 55%, respectively(1).

Participants lost about the same amount of weight over six months, an average of 6 kg, regardless of which group they were in; in general, metabolic risk factors also improved in all four groups.

In its coverage when the study was published, Dr Robert Eckel (University of Colorado Health Sciences Center, Denver) stated that the study affirms that people who are successful at losing weight are those who stick to a specific program. "Ownership, by the patient, of the weight-loss program is what proves successful, not the type of diet you chose," he said.

It really dismissed the notion that there's something clever about weight loss, showing that it really is about calorie consumption. "We all thought the statement made in that study was pretty profound," Yancy said. "It really dismissed the notion that there's something clever about weight loss, and that it really is about calorie consumption or, to make it even more straightforward, portion control. You can spend a lot of time wringing your hands about which diet and the composition of which diet, but it really is a simple equation of calories in and calories out."

Another analysis based on multiple studies that together indicated a 17% drop in estimated one-year risk of hospital admissions for acute MI in North American and European communities that adopted strong laws restricting smoking in public places, compared with rates in those communities before implementation of the restrictions (2). The risk declined steadily with increasing follow-up time.

And a combined analysis from the Coronary Artery Risk Development in Young Adults (CARDIA) study and Multi-Ethnic Study of Atherosclerosis (MESA) suggested that young adults with a low risk of developing heart disease over the short term (within 10 years) by conventional measures can be classified into high- and low-lifetime-risk groups [4]. Those with low short-term but high long-term risk were described as having a greater degree of atherosclerotic disease progression (3).

"This study is an important look at how the presence of risk factors early in life can be crucial to the lifetime risk of cardiovascular disease," according to the AHA. In its coverage of the analysis, heartwire quoted lead author Dr Jarett Berry (University of Texas Southwestern, Dallas), who said that even at younger ages, less than 50 years, "the clock is ticking" for many adults who are unaware that they already have progressive atherosclerosis.

Kardea Nutrition Serious Nutrition for Cardiovascular Health

Reference

(1)Sacks FM, Bray GA, Carey VJ, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009; 360:859-873.

(2)Lightwood JM, Glantz SA. Declines in acute myocardial infarction after smoke-free laws and individual risk attributable to secondhand smoke. Circulation 2009; 120:1373-1379.

(3)Berry JD, Liu K, Folsom AR, et al. Prevalence and progression of subclinical atherosclerosis in younger adults with low short-term but high lifetime estimated risk for cardiovascular disease: the Coronary Artery Risk Development in Young Adults study and Multi-ethnic Study of Atherosclerosis. Circulation 2009; 119:382-386.

Vitamin D Deficiency-A Potential Role in Cardiovascular Disease Prevention

2009-11-25T07:33:00.005-05:00

Inadequate levels of vitamin D are associated with an increase in the risk of cardiovascular disease and death, a new observational study has found. Dr Tami L Bair (Intermountain Medical Center, Murray, UT) reported the findings here at the American Heart Association 2009 Scientific Sessions.

Bair and colleagues followed more than 27 000 people 50 years or older with no history of cardiovascular disease for just over a year and found that those with very low levels of vitamin D (<15 ng/mL) were 77% more likely to die, 45% more likely to develop coronary artery disease, and 78% more likely to have a stroke than those with normal levels (>30 ng/mL). Those deficient in vitamin D were also twice as likely to develop heart failure as those with normal levels.

"We concluded that even a moderate deficiency of vitamin D was associated with developing coronary artery disease, heart failure, stroke, and death," said coauthor Dr Heidi May (Intermountain Medical Center). However, "it is not known whether this is a cause and effect relationship," she told heartwire. Because this study was observational, more research is needed "to better establish the association between vitamin D deficiency and cardiovascular disease," she noted.

Evidence so far suggestive of benefit of vitamin D

Vitamin D was the subject of much discussion in a general session on vitamins at the AHA scientific sessions. While there is strong evidence supporting the benefits of vitamin D in cardiovascular disease, there have been only a few randomized clinical trials, and previous observational studies "show no robust effects," said Dr Harald Dobnig (Medical University of Graz, Austria). The latter suffer from limitations, such as doses of vitamin D supplementation that are too low, low compliance rates, and short study duration, he noted.

There are some large randomized trials underway looking at outcomes with vitamin D; it is hoped that they will provide definitive answers in five to seven years, Dr Eric Rimm (Harvard School of Public Health, Boston, MA) explained.

"I think there's promise for vitamin D. We know that most people have insufficient vitamin D levels in their blood," Rimm says. "So although it will take five years until some of the trials that are adequately powered to look at cardiovascular disease with vitamin D will report, the epidemiology right now is suggestive that people should have 1000 or 2000 IU of vitamin D a day," he said.
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Kardea Nutrition, guided by the recommendations fo the National Cholesterol Education Program, enables each of us optimize the power of therapeutic nutrition to advance cardiovascular health, naturally and deliciously.

Beyond Bad Cholesterol---Low Good Cholesterol May Be Greater Issue

2009-11-20T10:39:00.009-05:00

As scientific knowledge advances, we gain a better understanding of the cholesterol challenge. Total cholesterol is no longer the focus. A primary focus on the absolute levels of LDL (bad) cholesterol is evolving to heightened interest in the LDL/HDL ratios, the total levels of HDLs (good cholesterol),the composition of the LDL cholesterol itself and the levels of inflammation. Here at Kardea, we continue to provide you information on the evolving science. The report below suggest that low HDL is a critical factor ---- perhaps more important than elevated levels of LDLs. From a treatment perspective,however, we simply have more tools --- both nutritional and pharmacological---to address elevated LDLs than to raise low HDL levels.

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Taking a statin to lower LDL or ‘bad’ cholesterol is of limited use in warding off the risk of heart attacks and cardiovascular disease unless low levels of HDL or ‘good’ cholesterol are also addressed, researchers from Tufts Medical Center in Boston, US have found.

The research team led by Dr Richard Karas, professor of medicine at Tufts University School of Medicine, examined the relationship between HDL cholesterol (HDL-C) and cardiovascular disease (CVD) risk in patients taking statins. While statin therapy does reduce CVD risk, the incidence of CVD events in statin-treated patients remains unacceptably high, they observed.

Karas' team identified 20 eligible randomised controlled trials of statins, with 543,210 person-years of follow-up and a total of 7,838 myocardial infarctions. The analysis revealed a significant inverse association between HDL-C and the risk of myocardial infarction. Every 10mg/dL reduction in HDL-C was associated with 7.6 and 7.8 more MIs per 1,000 person-years respectively in patients taking statins and in non-statin controls.

At the same time, statin treatment cut the risk of MIs by a median of 4.4 per 1,000 person-years.“While statins overall prevent four heart attacks per 1,000 patient-years, these new findings demonstrate that a 10-point higher HDL-C level could save an additional eight heart attacks per 1,000 patient-years, which indicates that, even if patients are on a statin, if they have low HDL-C, they may need more than just statins to significantly reduce their risks,” Karas commented.

“We believe most clinicians will be surprised to see the magnitude of the effect of low HDL-C on heart attack risk and how little statins impact the risk associated with low HDL-C,” he said.

The analysis also explored the association between HDL-C and cardiovascular disease, as well as coronary heart disease death, CVD death and all-cause death. In all these cases, the findings indicated that risk increased as the levels of HDL-C fell, and there were minimal differences between patients who were or were not taking statins.

Data from the Tufts Medical Center study were released at the American Heart Association Scientific Sessions 2009 in Orlando, Florida.

Mixing Meds---Another Alert

2009-11-19T08:28:00.004-05:00

Cholesterol managing medications remain the single largest class of drugs sold in the world. High blood pressure medications are not far behind. The reason: unlike a medication to treat an acute and passing infection, these medications are often taken for a lifetime.

Here at Kardea, we look to the power of therapeutic nutrition and other lifestyle changes to allow an individual achieve healthy heart results either without the medications or at least with lower dosage levels.

Our interest is motivated less by the potential power of a given medication to achieve the specific result. Rather, our interest lies with the fact that a given drug is likely to be appropriate for one health concern. Yet, as we age, we often will face multiple condition --- and we take multiple medications for each condition---sometimes simply to treat the side effects of the first medications. I certanly have been watching my 83 year old mother and 90 year old father add an another medication with each passing birthday. It is the cocktail of medications that I find alarming. The long term interactions among these drugs are uncertain....but each drug is a powerful chemical agent.

Here is a case in point:

On November 17, 2009, the Food and Drug Administration warned consumers not to take popular heartburn medications Nexium or Prilosec if they use Plavix, a widely prescribed blood thinner that guards against heart attack and stroke.

The two heartburn formulations can reduce the protective blood-thinning effect of Plavix, a medication widely advertised directly to consumers, by nearly one-half, according to a study undertaken at the request of the FDA.

Heartburn medications are commonly used with Plavix because it can cause upset stomach.

A leading medical industry watchdog welcomed the FDA's action, but said it's late and not forceful enough. The FDA should have required a more prominent "black box" warning, said Sidney Wolfe, director of Public Citizen's Health Research Group. "You're getting a less effective dose of a potentially life-saving drug," said Wolfe, who also is a member of the FDA's Drug Safety and Risk Management Committee. "This is a serious issue."

Kudos to Dr Wolfe and the FDA...but one can only guess that more than one patient taking both Plavix and on these heartburn medications was prescribed a higher dosage or this Plavix or treated with yet another medication.

High Cholesterol Under Treated in Many Americans

2009-11-18T09:45:00.002-05:00

NEW YORK (Reuters Health) - A US study on cholesterol released today contains both good and bad news:

The good news: Between 1999 and 2006, the number of adults in the US with high levels of artery-clogging LDL cholesterol, the "bad" cholesterol, decreased by about one-third.

The bad news: A high percentage of adults still are not being screened or treated for high cholesterol levels, putting their health in jeopardy.

Adults at greatest risk for heart attack and other heart-related "events" continue to have the highest prevalence of high LDL cholesterol, Dr. Elena V. Kuklina and associates at the US Centers for Disease Control and Prevention in Atlanta found.

The researchers studied trends in the prevalence of screening, current use of cholesterol-lowering medication, and high LDL cholesterol levels across four periods: 1999-2000, 2001-2002, 2003-2004, and 2005-2006. Overall, there examined data on more than 7,000 adults.

Between 1999-2000 and 2005-2006, the prevalence of high LDL cholesterol levels fell from about 32 percent to 21 percent, the investigators report in Wednesday's edition JAMA (Journal of the American Medical Association).

The prevalence of high LDL cholesterol varied significantly by risk category, however. In 2005-2006, the prevalence high LDL-cholesterol was 59 percent in individuals at high risk for heart-related events, namely those with a history of heart disease, chest pain, heart attack, stroke or diabetes.

The prevalence of high LDL cholesterol was 30 percent in those at medium risk for heart problems and 11 percent in those at low risk. Individuals were stratified as medium or low risk depending on their number of such risk factors as cigarette smoking, high blood pressure, family history of heart problems, and LDL and "good" HDL cholesterol levels.

In the high-risk group, more than 35 percent had not been screened for high cholesterol in the last 5 years and nearly 40 percent were either untreated or inadequately treated for high cholesterol. Roughly 20 percent of high-risk subjects were candidates for statins or other cholesterol-lowering therapy but were not receiving it.

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Kardea Nutrition-enabling a scientifically-validated nutritional approach to cholesterol management and cardiovascular health---works alone or as a complement to conventional pharmaceuticals. See Kardea White Paper.

Niacin Useful In Natural Cholesterol Management

2009-11-16T21:46:00.008-05:00

Hamden, CT Niacin available as non-prescription supplements can be an effective component of a broader natural nutritional approach to improve cardiovascular health and healthy blood lipids including cholesterol, a White Paper released by Kardea Nutrition reported.

Niacin, also known as Vitamin B3, is vital for good health. Niacin helps convert food into energy, build red blood cell counts, and synthesize hormones. For basic good health, a relatively small amount of niacin, about 20mg/day, is needed. Americans typically obtain this level from a balanced, healthy diet. Our bodies also can manufacture niacin.

At substantially higher levels—1000-2500mg/day--- a specific type of niacin significantly improves cholesterol levels. At these levels, Niacin as nicotinic acid can lower plaque-forming LDL cholesterol by up to 25%. It also has been shown to raise the healthful HDL cholesterol by as much as 35%, and lower triglyceride levels by 20% to 50%. The medical community defines these high dosages as a drug available that should be taken under a physician’s care. Nicotinic acid is available in a prescription form or as supplements.

Between the 20mg of niacin recommended to avoid a deficiency and the 1000+mg that may be prescribed by a physician lies niacin levels that has been shown to be useful in promoting a healthier cardiovascular system. The intake of nicotinic acid at 100-1000mg/day has been shown to significantly improve the levels of both HDLs and triglycerides. At these lower levels, niacin has not been shown to consistently lower LDL cholesterol levels.

Cholesterol Management: Beyond LDL Reduction

LDL cholesterol reduction has been the primary focus of the medical and pharmaceutical community. This focus is supported by the significant and extensive research confirming the positive health effects of lowered LDL, including reduced heart attacks, strokes and other cardiovascular diseases.

Increasingly, medical science now understands that LDL reduction alone is only part of solution in cholesterol management to promote cardiovascular health and wellness.

Researchers are expanding the targets to more broadly address the composition of cholesterol and triglycerides in our blood. For instance, the NIHs’ National Cholesterol Education Program (NCEP) reports that “strong epidemiological evidence links low levels of serum HDL cholesterol to increased heart disease. High HDL-cholesterol conversely conveys reduced risk.” The NCEP identifies HDLs less than 40mg/dl has a risk factor for heart disease. Levels above 60mg/dl are associated with a reduced risk of heart disease.

Low HDL levels without elevated LDL levels are fairly common. Up to 50% of patients not typically candidates for LDL lowering medications have low levels of HDLs. In patients with premature coronary artery disease, low HDL levels are the most common abnormality in blood lipids.

Many recent studies indicate that small increases in HDLs can significantly reduce the incidence of cardiovascular-related death. A 1mg/dl increase in HDL has been associated with a 2%-3% reduction in coronary artery disease. Another extensive study showed that increasing HDL by 6% in patients with low HDL cholesterol decreased heart related deaths and non-fatal heart attacks by 22%

Integrated Approach to Natural Cholesterol Management

Coupled with the HDL raising/LDL lowering benefits associated with niacin (nicotinic acid) LDL reductions can be achieved through the restricted intakes of saturated and trans fats, higher intakes of monounsaturated fats, and therapeutic levels of plant sterols and selected types of fibers (including soluble fiber from oats, barley, psyllium, beans and certain fruits) Modest weight loss and increased physical activity can further raise HDLs.

The White Paper is based on studies conducted over the past two decades and published in the various peer reviewed journals. The paper also addresses other issues associated with niacin intake including flushing and consumer confusion associated with the different types of niacin.

Aspirin, Cardiovascular Disease & Diabetes

2009-11-11T09:28:00.004-05:00

Writing in a paper published online in Britsh Medical Journal, Dr Giogria De Berardis and colleagues conclude that "a clear benefit of aspirin in the primary prevention of major cardiovascular events in people with diabetes remains unproved."[1]

"It seems that not only in individuals with diabetes, but also in all other high-risk groups, the efficacy of aspirin for preventing the development of cardioivascular disease is lower than expected. It doesn't mean that aspirin is not effective, it means that the efficacy is lower than expected, and that means we need to select very carefully the patients who are more likely to benefit."

Nicolucci points to another issue that warrants further exploration: whether there are specific characteristics of diabetic that make aspirin less likely to function as expected.
"There's strong basic research evidence suggesting that diabetes can represent a particular situation associated with poor response to aspirin. "

De Berardis G, Sacco M, Strippoli GFM, et al. Aspirin for primary prevention of cardiovascular events in people with diabetes: Meta-analysis of randomised controlled trials. BMJ 2009; DOI:10.1136/bmj.b4531. Available at: http://www.theheart.org/article/viewDocument.do?document=http%3A%2F%2Fwww.bmj.com.

Spirits for the Heart

2009-11-04T07:46:00.013-05:00

I often prefer a stiff drink over a glass of wine. At the end of a long week, I may seek a very dry martini or a good scotch to ease the accumulated stresses. For me, these spirits cut the edge. Neither beer nor wine provides the same remedy. One, maybe two, is all. Generally, not more than 2 times per week.

The prevailing wisdom, however, has been that wine is the healthier alternative. Wine may well be an important element in the Mediterranean diet, a way of eating associated with longer life, reduced risk of cardiovascular and cancer mortality and reduced risk of dementia and declines in cognitive function as we age. Wine contains micronutrients that are beneficial.

A study released by researchers at the Harvard Medical School and the Harvard School of Public Health found that liquors and beer deliver some of the same health benefits as wine (1). The study focused on the relationship between moderate alcohol intake and a reduction in inflammation.

Normally, inflammation is part of a healthy immune response that heals injury and fight infection But chronic inflammation is very different. Cancer, diabetes, depression, heart disease, stroke, Alzheimer's—these seemingly diverse diseases--are increasingly thought to have inflammation as a common denominator.

And the concerns around cholesterol and cardiovascular health also center on inflammation. LDL cholesterol, the type of cholesterol that can clog your arteries, is most seriously an issue when the arteries are inflamed.

A marker for inflammation is the compound C-reactive protein (CRP) that can be measured through blood tests. Assessing CRP levels is currently recommended for those at increased risk of heart disease. High levels of CRP are associated with future heart attacks and strokes.

Prior to the Harvard study, much research did indicate that moderate levels of alcohol consumption led to reductions in CRP levels. Most studies examining this relationship focused on a single type of alcoholic beverage. As a result, it remained uncertain whether the impact differed by the type of alcoholic beverage consumed.

The Harvard study compared CRP levels and alcohol consumption of 11,815 women. Some were beer drinkers. Others drank wine. And others drank liquors. Still others enjoyed some each. Overall, the association between alcohol and CRP levels were found to be related to alcohol consumption rather than the type of alcohol consumed.

Needless to say, the power of alcohol consumption was found to be less than the power of good eating habits, lower weight and physical activity. The results, however, are consistent with the general recommendation. Alcohol, in moderation, may well be a useful component in a healthy lifestyle. Cheers!

American Heart Association Recommendations: At this point, the AHA does not recommend drinking alcohol, but if you drink, AHA emphasizes moderation. Moderation means not more than one to two drinks per day for men and one drink per day for women. Too much can increase weight, triglycerides and blood pressure. Excessive drinking can lead to other serious heart problems.

(1) Levitan, B, Emily, "Association Between Consumption of Beer, Wine, and Liquor and Plasma Concentration of High-Sensitivity C-Reactive Protein in Women Aged 39 to 89 Year" The American Journal of Cardiology Volume 96, Issue 1, July 1, 2005, pp 83-88.

Slashfood Tweets

2009-10-15T22:07:00.001-04:00

Slashfood Tweets

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Wilted Spinach from Kardea Nutrition

2009-10-13T14:08:00.004-04:00

1 Pound Fresh Spinach
2 Medium Cloves Garlic, chopped.
1.5 Tablespoon Kardea Extra Virgin Olive Oil with Added Plant Sterols

Wash the spinach carefully. Often, spinach comes with bits of dirt that are really unpleasant when grinding between your teeth. To clean, fill a pot with water and drop leaves in. The heavier dirt particle will fall to the bottom while the leaves float. Leaving the water in the pot, remove the spinach, place in a colander, rinse and drain.

Heat a larger frying pan on a medium-low to medium heat. Add 1.5 tablespoons of olive oil. When oil is hot, add garlic and then quickly add the spinach to the pan. Cover tightly. After the spinach has wilted, stir to assure that oil and garlic lightly coat all the leaves.

Barley Pilaf-Soaking Up Your Sauces with a Great Tasting Cholesterol-Blocker

2009-10-13T13:57:00.004-04:00

An evening meal is not complete without the sauce-soaking, flavor-absorbing carbohydrate. Whether the potato, rice or bread, these carbs work to bring a meal together and enhance the dining experience. Unfortunately, these satiating carbs typically offer empty calories.

In the Kardea kitchen, we have found that barley offers a terrific alternative. Barley stands side-by-side with oats as an FDA-endorsed food for promoting heart health by lowering cholesterol. It is high in soluble fiber and a reasonable source of protein. I have since set out to explore how barley could be enjoyed in something other than a malted beverage.

As it turns out, a barley pilaf can be a delicious alternative to the rice, potato or pasta “starch” in protein/starch/vegetable triad my mom insists constitutes a meal.

A pilaf can be cooked to complement a great variety of dishes. Adapt by incorporating any number of spices. Start with the basic pilaf and create from there.

So, you ask “why don’t more people eat barley.” At least part of the answer lies with the fact that cooking barley can be a bit tricky. If you are not careful, you might find your pilaf with hot cereal qualities—perhaps great for a cold morning but not the best for a dinner. But if you take a bit of care, your barley pilaf can be a great nutritious alternative to high glycemic, low fiber carbs.

Barley Pilaf

4 Servings of About 1 Cup Each
Ingredients
1 Cup Rinsed Pearled Barley
2 Cups Water
1 Small Onion-Chopped Small
2 Tablespoons Extra Virgin Olive Oil (preferably fortified with plantt sterols)*
½ Teaspoon Turmeric
Salt & Pepper to Taste

*to double-up on the cholesterol lowering abilities of this dish, Kardea formulated an extra-virgin olive oil with added plant sterols. This olive oil is available through the Kardea Nutrition website http://www.kardeanutrition.com/products/food.aspx. Alternatively, if you want to lighten up on calories and total fat, you can cut the olive oil back to 1 tablespoon.

Direction
Heat a sauce pan over medium heat. When pan is hot, add olive oil and chopped onion. Saute for a few minutes. Add rinsed peal barley and saute for 5 or so minutes, stirring regularly and making sure that barley does not burn or stick to bottom of pan. Add turmeric and then water to the hot barley and stir. Cover, lower heat and cook until tender but still a bit chewy (30 minutes). Remove cover and on very low heat, let steam escape. Periodically fluff to prevent sticking to bottom of pan. Serve when barley appears about the consistency of steamed rice. This all may sound a bit cumbersome, but it works. The turmeric also gives the barley a beautiful yellow color, accenting the visual appeal of an entire meal.

Nutritional Facts
(about a cup of cooked barley pilaf)
Calorie: 240 Calories from Fat: 70
Total Fat: 8g from olive oil; monounsaturated: 5.7g; polyunsaturated fat: 1.15g; saturated fat: 1.15g (4.3% of total calories); Trans fat: 0.0g.
Cholesterol: 0.0
Total Carbohydrates: 40g; Total Fiber: 8g; Soluble Fiber: 2g.
Protein: 5g.
Plant Sterol: .25g

Stepping-Up
You can try adding any number of spices. Try curry or cumin when serving lean meats or roasted root vegetables. Try ginger and currents when serving fish. Serve with a kidney bean chili or black bean salad (recipe in next blog) to create a meal that delivers 3-4g of soluble fiber.

Do You Have A Great Barley Recipe? Can you improve this recipe? Post your thoughts and recipes to this blog to share with the Kardea community.

Salmon with Caper Berries, Vermouth & Apricot Preserve

2009-10-13T13:36:00.012-04:00

Serves 4

When it comes to heart healthy Omega-3s, not all fish are created equal. Salmon remains one of the the best source of these heart healthy fatty acids. Lighter, whiter fish like sole, flounder and cod have substantially less. Even then, different types of salmon can deliver significantly different amounts. According to the United States Department of Agriculture, some types can deliver nearly twice as much omega-3s as others:

Atlantic, farmed: 2.5g
Atlantic, wild: 2.1g
Chinook: 2.0g
Coho: 1.5g
Sockeye: 1.4
USDA Nutrient Data Laboratory Database, Release 18

The cooking method also can substantially alter the Omega-3 content. If you broil or grill, you are likely to lose more of the Omega-3s than if you poach. There are two reasons here. First, when grilling or broiling, more of the Omega-3 will drain out of the fish. Moreover, in poaching, the broth is typically consumed. Any Omega-3s that do drain out of the fish are still eaten. The lower cooking temperatures associated with poaching also preserve the benefits of the Omega-3s.

There are terrific poaching recipes, but if you prefer the taste and texture of the broiled salmon, here is a Kardea Gourmet recipe that blends the great taste of broiling with the benefits of poaching.

2.0 Pounds Salmon Filet (skin on)
½ Cup Dry Vermouth (or White Wine)
2 Tablespoons Apricot Preserve
12 Caper Berries (or 2 teaspoons of capers)

In your oven, heat a heavy pan under the broiler. When the heavy pan is hot, place in the salmon with the skin side down. After 3-4 minutes under the broiler, turn oven to 325 degree.

While fish is broilng, heat vermouth in a sauce pan and then stir in the apricot perserve. Pour vermouth/apricot mixture over fish when you reduce the oven heat. Bake uncovered for 5 minutes. Add caper berries and cover. Bake fish until done, typically another 7-8 minutes depending on the thickness of the fillet. Serve with Kardea's wholesome barley pilaf--great for soaking up the sauce---and a wilted spinach.

Kardea Gourmet Bars Receive Two 2009 Gear Awards

2009-09-28T14:48:00.004-04:00

Kardea's gourmet nutrition bars received "Top Gear of the Year Award" in the health and fitness category. Each Kardea bar delivers 7g of protein and 7g of fiber in only 150 delicious calories. The bars are formulated to promote cardiovasular health and exceed the FDA claims associated with heart healthy nutrition.

The ShapeYou.com GearAwards™ were established by health and fitness professionals to recognize outstanding products in the industry. The GearAwards are judged by a team of trainers, coaches, competitors, nutritionists, health care practitioners, industry writers, gym owners and sports, health & fitness retailers. Kardea is honored to meet the high standards of the Gear Awards for four of their products.

Both the Kardea Cranberry Almond bar and the Lemon Ginger bar received these awards.

Root Vegetables & Chick Peas from the Kardea Gourmet

2009-09-23T15:29:00.002-04:00

Makes about 8 servings

Parsnips star in this dish. A relative of the carrot, the cooked parsnip delivers a spicier, more pungent and sweeter experience. The carrots and turmeric add the color. The chick pea provides the body and the balance. The earthy notes of the porcini mushrooms complement the sweetness in this dish.

Nutritionally, a 5 ounce serving offers about 9g total fiber (about 3g of soluble fiber) and, thanks to the chick peas, 9g of protein. Low in sodium, this dish is a good source of potassium, delivering over 450mg/serving *.

2 Medium Sized Onions, Chopped
2 Clove Garlic, Chopped
2 Cups Chopped Parsnips1 Cup Chopped Carrots
2 Tablespoons Chopped Dried Porcini Mushroom
3 Cups Cooked Chick Peas
1 Tablespoon of Olive Oil
½ Teaspoon Tumeric
1 Teaspoon Paprika
Pinch of Coarse Ground or Kosher Salt
¼ Teaspoon Cinnamon (optional)

Heat a heavy skillet on a medium–low setting. When hot, add 1 tablespoon of olive oil and immediately added onions and garlic. Cover. Sautee for about 4 minutes. If onions appear to be browning, lower heat. Add parsnips, paprika and turmeric and carrots. Cover pan again and cook until the parsnips are soft. Add porcini mushrooms and chick peas. Cover and cook for another 15 minutes.

Nutritional Profile Per Serving (about 5 ounces):Total Calories: 210Total Fat: 5gFatty Acid Profile: 2.5g mono, 1.5 g poly, 1g saturated, 0g transProtein: 9gCholesterol: 0Carbohydrates: 34.0gTotal Fiber: 9gSoluble Fiber: 3gVitamin A: 55% RDIVitamin C: 15% RDIFolic Acid: 40%Potassium*: 450mgSodium: 30mgVitamin A: 20%Vitamin C: 54% RDI

* Epidemiological and animal studies indicate that the risk of stroke-related deaths is inversely related to potassium intake over the entire range of blood pressures, and the relationship appears to be dose dependent. The combination of a low-sodium, high potassium intake is associated with the lowest blood pressure levels and the lowest frequency of stroke in individuals and populations. Although the effects of reducing sodium intake and increasing potassium intake would vary and may be small in some individuals, the estimated reduction in stroke-related mortality for the population is large

Cardiovascular Health Improvements in US May Be Slowing-Possibly Reversing

2009-09-18T12:14:00.007-04:00

The number of American adults considered 'low risk' for heart disease has fallen below 10 percent, according to a new study, which places the spotlight on the growing need to address the risk via nutrition.

Published in the American Heart Association journal Circulation, the paper reveals that the progress in heart health that had been made during the 1970s and 1980s has now been reversed. According to the authors, only 7.5 percent of Americans between the ages of 25 and 74 were in the low risk category in 1999-2004. The figure for adults rated low risk was 10.5 percent in 1988-94.

The study, Trends in the Prevalence of Low Risk Factor Burden for Cardiovascular Disease Among United States Adults, created a low-risk index based on the following five factors:
• Not currently smoking• Total cholesterol below 200 (mg/dL) and not using cholesterol-lowering drugs• Blood pressure (systolic/diastolic) below 120/80 millimeters of mercury (mmHg) without using blood pressure-lowering medication• Body mass index (BMI) less than 25 kg/m2• Never diagnosed with diabetes.

Nutrition: Quantity & Quality

Adults at low risk of heart disease are those unlikely to develop cardiovascular disease or the associated risk factors. The researchers said that from a preventive health point of view, it was disappointing that less than 10 percent of Americans are meeting all the low-risk factors.
"Our analysis suggests that achieving low risk status for most US adults remains a distant and challenging goal. Unfortunately, the limited strides that were made towards this goal during the 1970s and 1980s were eroded by the increases in excess weight, diabetes and hypertension during more recent decades," said lead author Earl Ford of the US Public Health Services at the Centers for Disease Control and Prevention (CDC) in Atlanta, Ga.

The report found that while fewer adults are smoking, an increasing proportion are developing high blood pressure or diabetes or becoming overweight or obese.

While excessive weight continues to be a rising challenge, the quality of nutrition continues to play an important role in heart health promotion and disease prevention. Diets incorporating the right types of fibers, fats and other nutrients such as plant sterol and potassium can actively work to reduce blood levels of cholesterol, hypertension or the onsight of Type II diabetes. Yet, there remains tremendous confusion over nutrients and diets whose benefits are supported by strong science.

Source: Trends in the Prevalence of Low Risk Factor Burden for Cardiovascular Disease Among United States AdultsCirculation. 2009 Published online before print September 14, 2009doi: 10.1161/CIRCULATIONAHA.108.835728Authors: Earl S. Ford MD, MPH, Chaoyang Li MD, PhD, Guixiang Zhao MD, PhD, William S. Pearson PhD, and Simon Capewell MD

Walnut Basil Pesto -- Lighter, Healthier

2009-09-14T21:17:00.009-04:00

We grow a variety of herbs ---oregano, parsley, rosemary and basil-- in the Kardea garden. The oregano and rosemary retain wonderful flavors when they are dried, but the parsley and basil lose their zest. Pesto offers a great way to enjoy these herbs. The pesto also freezes well and can be enjoyed throughout the winter.

We have refined a standard pesto recipe to improve its heart healthy qualities. Sauteed walnuts replace the parmesan cheese, reducing both the sodium and saturated fat levels. The walnuts are a good source of L-arginine and ALA omega-3 fatty acids. Both these nutrients have been found to improve arterial function and blood flow. Moreover, the walnuts help maintain the great pesto consistence.

Both the basil and the parsley are a good source of anti-oxidants, particularly beta-carotene. Fatty acid ratio is a healthy 4:2:1 of monounsaturated: polyunsaturated: saturated.

Use over your favorite pasta or on sandwiches. A small dollop also can be used when serving a hearty soup.

Ingredients
4 Cups Fresh Basil Leaves, loosely packed
1 Cup Fresh Parsley, loosely packed
1 Cup Walnut
2/3 Cup Extra Virgin Olive Oil
4 Large Cloves Garlic, Chopped

Heat a pan over low heat. When hot, add 1/3 cups of olive oil, 3 cloves of chopped garlic and all the walnuts. Sautee 3-4 minute or until garlic is soft but not browned. Set aside and let cool.

In a food processor, add the second 1/3 cup of olive oil, the basil, the parsley and 1 clove of the fresh, chopped garlic. Blend with the sautéed walnuts.

Makes about 2 cups pesto. To freeze, place about .5 cup (enough for about a pound of pasta) in a small container. Cover with a thin coat of olive oil and freeze.

Admittedly, when serving with pasta, a bit of parmesan cheese brightens the dish, but keep it to a sprinkle. You will find that this pesto dish is far lighter than some of the more traditional pesto recipes.

Roasted Tuna with Rosemary

2009-09-12T12:53:00.005-04:00

Carving a roast at the table kicks off a great social meal. For heart health and cholesterol management, we have replaced the beef or pork tenderloin with tuna–a 3-4 pound filet.
You may be able to find this filet at your local grocery, but it is more likely that you will need to go to a fish store or upscale food market. Be prepared. They likely will ask what you are planning on making with this large chunk of fish.

Like any good roast, this tuna not only anchors a festive meal, but it also makes great sandwiches the next day.

3-4 Lbs Tuna (skinned whole filet, not steaks)
½ Fennel Bulb, chopped (optional)
2 Cloves Garlic, chopped (optional)
1 Teaspoon Kosher or Sea Salt (optional)

Marinade
½ Cup Olive Oil
1 Juice of a Medium Lemon
½ Cup White Wine preferably one that is not too dry.
2 Teaspoons Rosemary

Combine ingredients for the marinade and pour over tuna. Let stand in covered bowl outside the refrigerator for about 1 hour.

If you decide to use the fennel, prepare while the tuna is marinating. Beyond its lovely flavor, the fennel serves as a moist bed on which the tuna sits while roasting.

Heat a pan on medium heat and then add about 1/4 cup of the marinated, chopped garlic and fennel. Cover and cook until the fennel is tender, stirring occassionally (about 15 minutes). Remove from heat.

Preheat oven to 350 degrees.

Heat a large, heavy pan and coat hot pan with olive oil. Brown the tuna on all sides. If you opted to use the fennel, remove the tuna and place the sauted fennel on bottom of pan. Place the tuna on this bed of fennel . Pour the remaining marinade over the tuna and sprinkle salt. Cover and place in preheated oven. Roast for about 20-25 minutes. Remove from oven. Let this rest for about 5-10 minutes. Bring to the table. You are now ready to slice this tuna into meaty slices, serving medium-rare to medium slices. Spoon over gravy from pan.

Serves 6-8

Nutritional Profile Per 6 ounce Serving:Total Calories: 270Total Fat: Fatty Acid Profile: 7g mono, 2.5g poly, 2.5g saturated, 0g trans; Protein: 34g ; Cholesterol: 55mg; Carbohydrates: 1g; Total Fiber: 0g Soluble Fiber: 0g; Plant Sterols: 250mg (.25g) if using Kardea sterol-fortified olive oil; Omega-3s: 1.7g (Bluefin) Magnesium 20% Recommended Daily Intake (RDI)

Serve with a barley pilaf to enhance cholesterol-lowering benefits.

And if you have leftover, serve cold on a crusty roll with a slice of tomato, a few diced capers, a drizzel of olive oil & bit of dijon mustard.

Sea Scallop with Vermouth & Lemon Zest

2009-09-07T16:34:00.005-04:00

Matt Burg, a good friend, fellow foodie, and a lead Columbia University researcher in the relationships among stress, high blood pressure and heart attacks, and I were walking the trails of a Connecticut state park. I relayed to him a scallop dish that we had served the night before. Matt said he shied away from scallops because of the amount of butter (high in cholesterol-raising saturated fats) that he thought needed to be used to make a great scallop dish. This recipe will dispel him of such a belief. One serving not only provides a delicious protein, but it also delivers about 400mg of Omega-3s.

16 Large Sea Scallops
½ Cup Dry Vermouth
½ Teaspoon Fennel Seed, chopped fine
2 Teaspoons Lemon Zest, chopped coarse
1 Tablespoon Olive Oil
1/4 Cup Fresh Parsley, chopped coarse

On a medium setting, heat a pan large enough to place all the scallops on the bottom with some space between each. When hot, coat bottom with olive oil. Add vermouth and scallops. Cover for 3 minutes. Remove from heat and add lemon zest. Cover for another 1 minute. Add fresh parsley and serve.

Middle-Aged Cholesterol & Golden-Years Dementia

2009-08-12T09:03:00.009-04:00

Even moderately elevated cholesterol levels in midlife are strongly associated with later risk of Alzheimer's disease (AD) and vascular dementia (VaD), new research suggests [1].

Lead author Dr Alina Solomon (University of Kuopio, Finland) and colleagues used data from the Kaiser Permanente Northern California Medical Group to investigate the relationship between midlife cholesterol and dementia and found that cholesterol defined as "borderline high" of 200 to 239 mg/dL increase risk.

"Both physicians and patients need to know that elevated cholesterol increases the risk not only for heart disease, but also for dementia," Solomon said. "The most important finding was that even moderately elevated cholesterol at midlife can increase the risk of both AD and VaD later in life."

The study is published in the August 2008 issue of Dementia and Geriatric Cognitive Disorders.
The study included 9844 subjects who had undergone detailed health evaluations during 1964 to1973, when they were ages 40 to 45 years.

Comparing those with cholesterol below 200mg,dL, the analysis showed Alzheimer's disease hazard ratio for midlife borderline cholesterol (200-239 mg/dL) and 1.57 for high cholesterol (>240 mg/dL).

The risk of vascularr dementia hazard ratios were 1.50 for borderline cholesterol and 1.26 for high cholesterol.

Dr Robert Stewart (King's College London, UK) said that the Solomon study data are "convincing." "In general there is now a large body of evidence that indicates that what is bad for the heart is bad for the brain—that is, that the well-known risk factors for coronary heart disease and stroke are also risk factors for dementia (whether this is classified as Alzheimer's disease or vascular dementia)," Stewart said. [2]

"So the real message for clinicians is not to do anything differently, but to be aware that what they should be doing already—identifying and treating high cholesterol, high blood pressure, and diabetes and promoting healthy diet and active lifestyles—is likely to have more benefits than originally envisaged and should reduce risk of dementia as well as reducing risk of cardiovascular disease."

Kardea Nutrition enables cholesterol lowering and heart healthy diets.

[1] Solomon A, Kivipelto M, Wolozin B, et al. Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement Geriatr Cogn Disord 2009; 28:75-80
[2] Kelly, Janis Elevated cholesterol in midlife increases dementia risk. The Heart.Org August 11, 2009.

Cholesterol Lowering Foods: A Gourmet Meal Plan from Kardea Nutrition

2009-08-07T16:16:00.015-04:00

The science is clear and convincing. Therapeutic nutrition ---integrating a number of nutrients that actively alter cholesterol production, absorption and composition--- can help achieve cholesterol lowering comparable to many of the widely prescribed medications.

What are these active nutrients? The list below is generally consistent with the recommendations of the US National Institutes of Health National Cholesterol Education Program.*
Kardea Nutrition is on a mission to provide cholesterol lowering foods and cholesterol lowering recipes that allow you to achieve these nutrients, each and every day. Here is a goumet lunch & dinner meal plan (good for a Summer Sunday) that is both heart healthy and inspired. It delivers:

2+g of natural plant sterols from foods and taken through the course of the day
30g of total fiber
7g of heart healthy soluble fiber
1g Omega-3 fatty acids (EPA/DHA)
Ony 150mg of dietary cholesterol

Less than 7% of calories from saturated fats

About 20% of calories from cholesterol-improving monounsaturted fats.

This cholesterol lowering menu simply needs a bit more of the right kind of soluble fiber to meet the recommendations of the National Cholesterol Education Program. Look to breakfast to achieve the NCEP recommendations. A good morning start would be an oat cereal and fruit. The minimum recommendations for soluble fiber will be met.

In my life, I shoot for the higher 20-25g recommendation for viscous soluble fiber. Each morning, I dissolve in juice a blend of a concentrated oat fiber, ground psyllium husk and a dispersable plant sterol--a new product from Kardea Nutrition. One tablespoon of this blend delivers about 7 grams of heart-healthy soluble fiber and another 500mg of plant sterols.

Remember-this is not simply a low cholesterol meal plan; it is a collection of cholesterol-lowering foods.

Luncheon

Mediterranean Salmon Salad
Chick Peas with Oregano
Roasted Asparagus
Whole Wheat Roll

Snack

Kardea Gourmet Nutrition Bar

Dinner 1st Course

Gazpacho: Quick, Bold & Delicious

2nd Course

Chicken Balsamic Reduction Barley Pilaf

Steamed Broccoli

Dessert

Kardea Gourmet Wellness Bar

Sorbet of Your Choosing Fresh Berries or Sliced Ripe Peaches.

*Niacin is addressed in the National Cholesterol Education Program but substantially in the context of high doses prescribed by a doctor. Click for information on niacin in intermediate doses

red yeast

2009-08-01T10:26:00.000-04:00

More Than an Apple-A-Day: Multiple Portions of Fruits & Vegetables Heart Healthy

2009-07-27T12:03:00.006-04:00

A number of studies have linked higher fruit and vegetable consumption and reduced risks of coronary heart disease and stroke. The findings are based on the epidemiolgical studies of large groups of people. Epidemiological evidence remains open to strong challenge as the causal relationships can be difficult to support. Are the nutrients in fruits and vegetables working directly to reduce the risk of disease? Or is it that people who eat more fruits and vegetable simply reduce their intake of the foods containing heart unhealthy nutrients---saturated fats, trans fats, salt? Or is there yet some other factor involved.\? The American Heart Association (AHA) has found the result sufficiently signficant to recommend increasing fruit and vegetable consumption as part of a heart healthy diet.

A new clinical study, published in Circulation (volume 9, no 16 april 28 2009, pp2153-2160) has identified a causal relationship. Specifically, the study found improvements in arterial health with 6% increase blood flow response for each additional portion of fruit and vegetables consumed daily.

In responding to the efforts to identify the active compounds in fruits and vegetables, the study's authors comment that rather than searching for the single magic bullet micronutrient, a more practical approach is likely to consider whole foods and associated dietary patterns. Thus, increasing fruit and vegetable consumptions is likely to have numerous beneficial effects due to synergistic effects of bioactive compounds.

So look beyond the apple-a-day to keep the doctor away. Multiple portions of fruits and vegetables--- each with different compounds that may work together to improve heart health---is recommended.

Cholesterol Lowering Videos-Web MD & Kardea Nutrition

2009-07-07T08:10:00.004-04:00

Two videos --- one at Web MD and one at Kardea Nutrition --- offer insight into the power of nutrition to lower cholesterol. This power extends beyond avoiding foods high in cholesterol; it looks to nutritions that actively affect your body chemistry to improve (and lower) how you absorbs and metobolizes the cholesterol naturally produced by your body. These active nutrients include plant sterols, selected soluble fibers and selected fatty acids. Click on the links below to view.

Kardea Nutrition Video
Web MD Video

Shellfish, Mediterranean Diet & Cholesterol

2009-07-06T08:51:00.004-04:00

Open any book on the heart-healthy mediterranean diet and you are likely to see recipes celebrating all sorts of shellfish.

While all shellfish, particularly shrimp, are a source of dietary cholesterol, many also deliver significant levels of Omega-3s. Mussels, for instance, deliver more of these heart-healthy fatty acids than many fin fish, and deliver an amount equivalent to a swordfish or albacore tuna. Oysters provide even higher levels.

Shellfish also are low in fat–only 10% in shrimp, about 20% in mussels and oysters. Enjoy grilled shrimp, mussels marinara, clams with linguine, or sauted scall0ps as exciting alternatives to red meats typically higher in the unhealthy saturated fats. Scallops and shrimp also freeze well. Store a few pounds of each in the freezer for a quick and delicious meal. Canned clams can awake a mid-week pasta dish and deliver an significant level of Omega-3s. Even fresh mussels, clams or oysters can be stored in your refrigerator for a few days—but remember, do not store in an air-tight bag. These mollusks need to breath until cooked.

Overall, the benefits of shellfish consumption — particularly to the extent that they enable you to dramatically reduce the consumption of higher saturated fats in red meats and dairy products and increase the weekly intake of Omega-3s from marine sources—outweighs the cholesterol. Remember: most of the cholesterol in our bodies is produced by our bodies. It does not come from the food we eat. Further, look to pair your shellfish with foods high in plant sterols and selected soluble fibers to block cholesterol absorption into the blood stream.

Lifestyle Changes Before Statins for Individuals wiith High CRP

2009-06-30T11:05:00.000-04:00

Recent studies, notably the JUPITER study published in the New England Journal of Medicine, reinforces the evidence that reducing the level of inflammation in the arteries as measured by C-Reactive Protein (CRP) levels may reduce the development of arterial plaque. The Jupiter study also was focused on the role of cholesterol-lowering medication (the statin, Crestor) to reduce both LDL (bad) cholesterol and CRP. The positive results of the study suggested that many more people --- even those with otherwise good cholesterol levels but with high CRP levels---be prescribed these medications.

Not so fast, suggests Doctor Roger Blumenthal, director of the Johns Hopkins Center for Prevention of Heart Disease. In an online interview, Dr Blumenthal emphasizes that lifestyle changes, including dietary changes, are the appropriate course of action.

Kardea Nutrition-Heart Healthy & Inspired-enabling cholesterol management, naturally and nutritionally.

Mediterranean Diet Works As A Whole System

2009-06-29T08:38:00.007-04:00

Researchers continue to find an association between the Mediterranean diet and increased longevity.

"Overall diet is more important than individual components, with emphasis on moderate—but not excessive—wine consumption, particularly during meals, preference for olive oil as the main added lipid, low consumption of meat, and high consumption of vegetables, fruits, and legumes," author Dr Dimitrios Trichopoulos (Harvard School of Public Health, Boston, MA).

The researchers examined data from healthy individuals in Greece who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) trial.
The researchers looked at data from the Greek segment of EPIC, from over 23 000 healthy men and women aged 20 to 86 at enrollment. As is typical in the Greek population, many individuals were overweight or obese and many men were smokers. Most were moderately active.

This work confirms that it is not one single component of the Mediterranean diet that is driving reduced risk of mortality. "In order to promote longevity, people have to do several things at the same time. They just can't focus on one food—just eat blueberries or take a folic-acid pill. It's a whole lifestyle, whole diet approach for health promotion," say Dr. Teresa Fung of the Harvard School of Public Health.

Report to Doctors: Dietary Interventions for Cholesterol Lowering Effective but Underutilized

2009-06-24T18:18:00.002-04:00

Dietary intervention to lower serum LDL-cholesterol (LDL-C) is effective, yet underutilzsed in general family practice, reports a June 2009 article published in the Australian Family Physicians journal.

A year long trial showed an average LDL cholesterol lowering of 13%, with about one-third of subjects achieving a reduction greater than 20%. An important difference in the results related to the individual's adherence to dietary advice. The most effective dietary strategies are replacing saturated and trans fatty acids with poly- and monounsaturated fats and increasing intake of plant sterols. Losing weight and increasing soluble fibre and soy protein intake can also lower serum cholesterol and may be considered when recommending a nutritionally balanced, cholesterol lowering diet.

Major Study Looks to Nutritional Supplements & Heart Health

2009-06-24T07:55:00.005-04:00

Boston researchers are launching a large, national trial of vitamin D and fish oil to see whether the dietary supplements reduce the risk of developing cancer or cardiovascular disease. They are also testing the idea that lower levels of vitamin D might explain higher rates of these diseases among African-Americans.

Boston researchers are launching a large, national trial of vitamin D and fish oil to see whether the dietary supplements reduce the risk of developing cancer or cardiovascular disease. They are also testing the idea that lower levels of vitamin D might explain higher rates of these diseases among African-Americans.

Dr. JoAnn Manson and Dr. Julie Buring, both of Harvard Medical School and Brigham and Women’s Hospital, hope to enroll 20,000 healthy older people in the $20 million study funded by the National Institutes of Health.

One quarter of the participants will be black. The researchers believe higher rates of cancer, heart disease, and stroke among blacks, compared with whites, might be related to dark skin’s lower ability to make vitamin D from absorbing sunlight, and they want to establish whether taking vitamin D supplements could reduce or eliminate these disparities.

“African-Americans have a higher risk of vitamin D deficiency and a greater frequency of certain types of cancer and diabetes and hypertension, so I think that it will be of great importance to look at whether something as simple as taking a vitamin D supplement can narrow these health gaps,’’ said Manson, who believes the study is one of the first large-scale randomized trials to target a specific group at higher risk for a deficiency of nutrients. “It would be wonderful if something as simple as a vitamin D pill could narrow that health gap.’’

Women over 65 and men over 60 with no history of cancer or cardiovascular disease will be randomly assigned into four groups.

Some will take daily pills with about 2,000 international units of vitamin D and about 1 gram of fish oil. Others will take pills containing no active ingredients. In the two other groups, participants will get one of the supplements and one placebo. “I think it’s important to be cautiously optimistic and not jump on the bandwagon to take megadoses of supplements before a clinical trial helps to clarify their role.’’

Treatment will last five years. Participants will not need to travel to Boston because study forms and pills will be mailed, according to www.vitalstudy.org, the website for the study.

_________________
Selected nutrients already have been found to promote cardiovascular health, notably plant sterol, soluble fibers from oatmeal, barley, psyllium and beans, and mono and polyunsatured fats in place of saturated fats. For more information on nutritional approaches to cardiovascular health, go to Kardea Nutrition. For heart health cooking recipes incorporating these key nutrients, go to Kardea Gourmet

Cardiovascular Disease: The Number 1 Killer of Women

2009-06-24T07:34:00.003-04:00

So you think that cardiovascular disease is primarily a problem for men. Think again: More than 500,000 women in the U.S. die each year of cardiovascular disease, making it their No. 1 killer.

In fact, for a variety of complex reasons, the condition is more often fatal in women than in men and is more likely to leave women severely disabled by a stroke or congestive heart failure.

True, women don't usually start showing signs until their 60s--about 10 years after men first develop symptoms. And hormones seem to play a protective role in women before menopause.

But the common belief that premenopausal women are immune to heart problems is just plain wrong. Heart attacks strike 9,000 women younger than 45 each year.

The more scientists learn about a woman's heart and what can go wrong with it, the more they realize that females aren't just small males. There are subtle but important differences in how women's cardiovascular systems respond to stress, hormones, excess saturated fat and toxins like tobacco. There are also some pretty big differences in how aggressively doctors treat women with heart trouble--even in the emergency room when they are in most desperate need of help.

"The vast majority of heart attacks in women could be prevented with a combination of lifestyle modifications and medication," says Dr. JoAnn Manson at the Brigham and Women's Hospital in Boston. "Just making use of existing information could nearly eradicate the disease."

Of course, neither men nor women can do anything about their age or the genes they were born with. (If your father had a heart attack before 55 or your mother had a heart attack before 65, you should pay special attention to your heart health.) And it's still unclear why heart disease seems to strike men and women so differently. Structurally, their hearts and arteries are basically the same; women's hearts are smaller, but in proportion to their bodies. So doctors are pretty sure that any differences are matters of degree rather than kind.

Cardiologists are confident that they understand how heart attacks occur in men. The trouble usually begins when a fatty deposit or plaque, which has taken decades to build up on the inside of a coronary artery, becomes unstable and bursts, triggering a clot that blocks a blood vessel. Doctors can see these plaques during a fairly invasive procedure called an angiogram, in which a catheter is threaded through an artery in the groin or leg up to the arteries of the heart and a dye is then released to make any blockages easier to spot.

Although the research is controversial, some evidence suggests that bursting plaques may not be as important for women as for men. Doctors have long puzzled over the fact that some of their female heart-attack patients--usually those who have not yet gone through menopause--show few signs of artery-clogging plaques on their angiograms. Perhaps their blockages don't occur in the major arteries of the heart, where angiograms are performed and bypasses are most effective. Perhaps blood flow is restricted in the smaller vessels that branch off the coronary arteries. And perhaps the problem isn't plaques at all but the fact that these smaller blood vessels are somehow more prone to spasm, snapping shut at the slightest stress or trigger, cutting off the flow of blood to parts of the heart.

It's also possible that plaques--whether in the main coronary arteries or the smaller vessels--behave differently in women. Unlike men, women tend to distribute all the "garbage" associated with atherosclerosis--such as saturated fat and oxidized waste products--more evenly throughout the arteries. The process is analogous to the way men and women gain weight, says Dr. Noel Bairey Merz of the Cedars-Sinai Medical Center in Los Angeles. "When men get fat, it all goes to their belly," she says. "When women get fat, they tend to get fat all over--fat at the ankles, fat in the sides, fat in the upper arms." So although women generally avoid the monster plaques that kill so many men in early middle age, the continuing buildup in women's arteries may come back to haunt them in their 50s, 60s, 70s and 80s.

Plaques are another reason for women to throw away their cigarettes, as smoking seems to turn stable plaques into unstable ones. "If you look at the plaque under a microscope, it doesn't appear to be the kind of plaque that can become unstable and rupture," says Dr. Robert Bonow of the American Heart Association. "But the surface has become eroded, exposing the material beneath the surface to the blood, which causes blood clots. And it turns out that the women who have this plaque erosion tend to be women who smoked." Those clots can travel through the bloodstream, wreaking havoc in the heart or the brain.

Kardea Nutrition--Delivering Therapeutic Nutrition for Cardiovascular Health, Naturally.

Plant Sterols & Omega-3s Combine To Boost Heart Health

2009-06-11T16:59:00.008-04:00

A combination of fish oil and plant sterols demonstrated over a 22% reduction in overall cardiovascular risk. In the September 2008 publication in Atherosclerosis, the researchers reported that they failed to demonstrate similar result for individuals taking fish oil alone.

The study's authors', Michelle A Micallef, University of Newcastle, and Manohar L, Garg, Hunter Medical Research Institute, write, "to date, this is the first study to investigate the combined cardioprotective effects of these two functional foods" in individuals with high cholesterol but without history of heart disease. The authors' conclude that the combine use of fish oil and plant sterol therapy is "an ideal alternative or adjunct to pharmacological treatments, for maximum cardioprotection ih high risk individuals."

Kardea Nutrition delivers a system of products that enable combination therapy, offering delicious foods and quality supplement. The Kardea system extends beyond fish oils and plant sterols to include cholesterol-lowering fiber and monounsaturated-rich extra-virgin olive oil.

Strategies to Increase Good HDL Cholesterol

2009-05-31T15:48:00.005-04:00

When it comes to cholesterol, most people think lower is better. But when we're talking about the cholesterol in our blood, it's a bit more complicated.

Low-density lipoprotein, or LDL, is known as the "bad" cholesterol and high-density lipoprotein, or HDL, is known as the "good" cholesterol. LDL optimally should be less than 100 mg/dL (milligrams per deciliter)---above this level, some amount of arterial plaque (the stuff that causes blocks in the arteries that can lead to heart attacks and stroke) is likely to develop. You and your doctor may or may not seek to lower your cholesterol levels if they are higher. This depends on a variety of risk factors. To assess your maximum LDL targets, click to the Kardea LDL Cholesterol Calculator based on the recommendations of the National Cholesterol Education Program. And if you are at high risk of heart disease, you and your doctor may seek to drive your cholesterol below 70mg/dL.

HDL cholesterol removes excess cholesterol from the blood, which slows the build-up in the arteries and ultimately lowers heart disease risk. Since estrogen increases HDL, women tend to have higher levels than men. Women should strive for an HDL above 50 mg/dL and men above 40 mg/dL. While genetics plays a role in your HDL level, there are some things you can do to modestly boost a sagging HDL:

Lose weight if you're overweight. Exercising and cutting a few calories can give HDL a little boost, especially if you carry most of your excess weight in your abdomen.
Quit smoking. Smoking, as well as secondhand smoke, can lower HDL.
Recognize that different types of fats affect your HDL levels. Healthy fat choices such as omega-3s found in fish and monounsaturated fats found in olive oil and canola oil, nuts, seeds and avocados should be used---replacing the satured and trans fats found in processed foods, certain meats and dairy products.
• Alcohol can raise HDL. If you can safely fit alcohol into your eating plan, keep it moderate -- no more than one drink a day for women and two drinks for men.

Also, you can consider the use of niacin as nicotinic acid. Available as both a supplement and a prescription medication, this form of niacin can significantly raise your HDLs. For an overview on niacin, read Kardea's discussion paper. And remember, in developing a program that optimizes your heart health and cholesterol profiles, it is best to collaborate with your health care professionals.

Looking Beyond Lowering LDL Cholesterol

2009-05-28T10:15:00.005-04:00

The risk of developing cardiovascular diseases is typically assessed based on a standard cholesterol test measuring LDL (low-density lipoprotein) and HDL (high-density lipoprotein) levels and then factoring advanced age, gender, family history of heart disease, high blood pressure, diabetes, and smoking. Taking these factors into account, LDL lowering targets can then be established, and a program of therapeutic changes in lifestyle and nutrition can be established. If these changes are unable to bring cholesterol levels in line, medications are routinely provided.

However, studies indicate that these risk factors can account for only a portion, perhaps 50%, of the incidence of coronary artery disease. The scientific community has continued its investigations, and is finding that a number of other risk factors can be identified through blood test. On its website, Berkeley Health Lab, a leading medical lab with an integrated program for cardiovascular treatment, identifies many of these important factors including:

Size of LDL Particles: Some LDLs Are Worse Than Others

Small LDL particles can cause plaque build up to progress much faster because they can enter the artery wall easier than large LDL particles
Too many small LDL particles can increase your risk for a heart attack beyond any other risk factors you may have, such as smoking, high blood pressure, diabetes, etc.
Certain medications, proper nutrition, and regular exercise can help your body produce fewer small LDL particles

Size of HDL Particles: Some HDLS Are Better Than Others

HDL helps to protect against progression of plaque build-up in the artery wall
HDL2b is the workhorse of all of the HDL particle types. It has the ability to pick up and remove cholesterol
Certain medications, improved nutrition, loss of body fat, stopping tobacco use, and increased physical activity are some ways that HDL-C and HDL2b can be improved

Apolipoprotein B: Accurate LDL Particle Number

ApoB is a direct measurement of the amount of LDL ("bad" cholesterol) particles
A high apoB number indicates increased risk for heart disease
Improved eating habits, increased physical activity, and loss of body fat are some lifestyle changes that improve apoB
Your physician uses apoB to determine if certain medications are needed and to monitor their effectiveness

C-Reactive Protein-hs (CRP)

High levels of CRP indicate inflammation within the body due to infection or tissue injury; it can also predict heart disease risk levels
Certain medications may help reduce this risk
Certain foods have anti-inflammatory benefits

ApoE Genotype

ApoE is a genetic test that plays a role in helping to identify how people respond to different amounts of dietary fat. Your body's response to dietary fat impacts the formation of small or large LDL particles
There are 3 types of apoE genotypes: apoE2, apoE3 and apoE4
People with an apoE4 have a greater risk for heart disease
ApoE can be used to help guide the right nutrition plan for you

Other risk factors measurable through blood tests also are discussed on this site.

Overall, most of us typically receive the standard test for cholesterol, with these more thorough tests reserved for those individuals at high risk. Yet, for those of us interested in the information needed to optimize our long term health, this more complete assessment can be very useful. Check with you healthcare provider about obtaining these more extensive blood test to better direct your unique course for optimizing your health.

Kardea Nutrition Links Dietitians & Natural Foods Retailers with Natural Cholesterol Management Speakers’ Bureau

2009-04-20T12:20:00.009-04:00

Lifestyle changes emphasizing therapeutic nutrition offer significant opportunities to positively affect a range of interconnected health issues --- including cholesterol management, metabolic syndrome, diabetes and hypertension. Generally, where these multiple issues occur, the importance of cholesterol management is amplified.

The challenge: consumers are often confused or misinformed in regard to the best ways to use nutrition to naturally improve cholesterol levels. Numerous studies, including those reviewed by the Food & Drug Administration, the American Heart Association and the National Institutes of Health, have shown that a 20-30% reduction in LDL cholesterol levels is readily achievable with nutritional therapy.

As part of an initiative to enhance consumer understanding, Kardea Nutrition is developing a program to link food retailers, particularly natural foods retailers, with registered dietitians.

Among the components of this Kardea initiative is the creation of a Natural Cholesterol Management Speakers’ Bureau. As part of this program, dietitians with proven expertise in cholesterol management will be providing in-store classes that address the integrated roles of fiber, plant sterols, niacin, omega-3s, and monounsaturated fats.

Nutritional health professional and natural foods retailers interested in participating in this program should contact Kardea Nutrition directly at customerservice@kardeanutrition.com.

Kardea Gourmet Bars: What Dietitians Are Saying

2009-04-16T19:53:00.005-04:00

Here at Kardea Nutrition, we are on a mission to enable cholesterol management through a nutritional, natural approach. For some, this approach allows the individual to avoid the need for prescription medications. For others, it allows for sharply lower doses of these medication to achieve targeted cholesterol levels. For all, it offers an opportunity to optimize our longer term health.

While we are here to provide the products that better enable this lifestyle, the dietitians and nutritionists are in the field working with individuals each day to change lifestyles and create healthful eating habits. We are reaching out to these health profressionals across the country. Here are some responses that we have received:

"Thanks so much for sending the samples of the Kardea bars. The bars are great and the breakdown is just perfect - especially since I've been trying to find more products we can carry here with sterol esters."—Susan, MS, RD, LDN, Urbana, IL.

"They are fantastic! Love the fiber content and that you are using psyllium. … Many thanks." Stacey RD, CPT, Santa Monica, CA

"I love the bars. Thanks."---Jennifer MS, MPH, RD, Massachusetts (Corporate Wellness Manager)

"I received your samples, and tried one myself. It was very good. Will recommend to my patients. Thank you."---Vickie , MS, RD, CDE, Maryland

"I spoke with you earlier about your great product. I work for in the Employee Wellness Department at a major insurance company and we are actively seeking better for you products for our cafeteria. Additionally, we offer cholesterol screenings, health fairs, diabetes classes, etc. I am sure you will find great opportunities for both you and our company." ---Judith RD, LDN, CDE, Texas

"We are selling your bars like hot cakes."--Sarah, RD, LD, Iowa, In-store dietitian.

"Hi-I am a registered dietitian working for a company whose mission is to personalize the treatment of patients threatened with cardiovascular disease. A colleague of mine in NY mentioned she had sampled your product and was recommending it to her patients. I wondered if you might supply me with a sample as well. Thank you."--Stacey, RD, LD, Alabama

"Even as I write this I am preparing a presentation on the ‘role of foods and a sensible diet to manage cholesterol and heart health’ for an elite group of ADA spokespersons. I intend to showcase Kardea bar and oil in my presentation."---Kantha, PhD, Illinois.

Updated Mediterranean Diet Pyramid From Oldways

2009-04-16T17:56:00.006-04:00

Despite the fact that calories from fats may account for upwards of 40% of a Mediterranean diet, many studies show reduced incident of cardiovascular diseases in those populations that follow the traditional eating habits of this region.

Certainly, there is no single Mediterrean cuisine. The aromas, flavors and recipes vary widely from Spain and Italy to Greece and Lebanon and then across North Africa. Moreover, not all foods of these regions are necessarily healthful. Oldways, a leading advocate of traditional, healthful eating has released a revised Mediterranean diet pyramid to provide clear direction.

The major change in this updated Mediterranean Diet Pyramid, writes the staff of Oldways, is that all plant foods (fruits, vegetables, grains, nuts, legumes, seeds, olives and olive oil) are grouped together to emphasize the health benefits they provide. A new addition to the Mediterranean Diet Pyramid is herbs and spices—for reasons of both health and taste. Increasingly, nutritional science is identifying active micro-nutrients in herbs, spices and other plant compounds that collectively may deliver health benefits well beyond what is provided by the better known vitamins, minerals, proteins, fats and carbohydrates.

The Oldways pyramid also points out the healthfulness of fish and shellfish, and suggest that it is beneficial to eat fish and shellfish at least two times per week.

Other specific recommendations of Oldways include:

Make olive oil your primary source of dietary fat
Eat low to moderate amounts of cheese and yogurt daily
Drink a moderate amount of wine (one to two glasses per day for men, one glass per day for women)
Snack on almonds instead of fat-free cookies.
Spread avocado on a sandwich to replace the mayonnaise.

Juvenile Diabetes & Cholesterol Management

2009-04-11T14:32:00.006-04:00

Diabetes is not simply a challenging and chronic disease in its own right, but it also is a leading risk factor for cardiovascular diseases.

As a consequence, those with diabetes, including children and teenagers, are encouraged to take a more active approach to managing cholesterol levels. The American Academy of Pediatrics, for instance, recently recommended wider cholesterol screening for children. Underpinning these recommendations is the understanding that elevated LDL (bad) cholesterol in kids can lead to an onset of cardiovascular disease earlier in adulthood. It recognizes that the plaque in an adult's arteries may have begun developing very early in life.

The AAP also suggested that for a selected group of children, prescribing a statin medication might be appropriate. Drug treatment, according to these recommendations, should be considered for children 8 and older who face multiple risk factors for developing heart disease.

Yet, statins are not typically considered the first line of treatment. Instead, medical nutrition therapy is recommended. Medical nutrition therapy includes the following: decreasing saturated fat (less than 7% total daily calories), avoiding trans fatty acids, decreasing dietary cholesterol to less than 200 mg daily, increasing soluble fiber from oats, beans, psyllium or fruits, and adding plant sterols daily.

In a recent study published in Diabetes Education, the role of medical nutrition therapy was evaluated in a patient with Type II diabetes. The patient achieved a desired LDL cholesterols level through nutrition alone. Medications were not required.

The Study's author concluded that evidence-based nutrition guidelines have been evaluated and reviewed to demonstrate the effectiveness of heart-healthy eating for children with hyperlipidemia and type 1 diabetes.

Maximizing Sterol Effectiveness: Study

2009-02-09T08:21:00.016-05:00

A recent study, published in Food & Nutrition Research (January 2009), found that while sterols uniformly worked to lower LDL cholesterol, their power is affected by a number of factors. The study assessed 59 randomized clinical trials published from 1992 to 2006. Maximum results were found where patients:

Consumed 2.5 grams of sterols or stanol per day. The FDA allows a health claim for products containing as little as .4 grams of plant sterols or .65 grams of plant sterol esters. As such, individuals will often need to take multiple servings of plant sterol products to attain the optimum daily intake. Consumption beyond 2.5 grams did not lead to further reductions ( Foods with Plant Sterols).
Took plant sterols over the course of the day. Multiple servings were generally found to be more effective than a single serving.

Not surprising, sterols lowered LDL cholesterol by more among individuals with high or very high cholesterol levels, but sterols also proved effective among individuals with optimal to borderline-high LDL cholesterol. The authors also sought to assess the power of sterols across different types of foods. While they generally found that foods with some fat content (greater than 3 grams per serving) and low-fat milks and yogurts may be somewhat better, the evaluation does not appear to control for other elements of diet, lifestyle and medications. More research in the role of plant sterols coupled with a broader approach to therapeutic nutrition for cholesterol management is merited.

Foods with Plant Sterols

2009-01-05T09:37:00.006-05:00

Plant sterols are an effective nutritional tool for lowering LDL cholesterol by 10-15%. As part of a diet that is both low in saturated fats, trans fats and cholesterol, and high monounsaturated fats and soluble fiber from oats, beans, barley or psyllium, individuals can achieve cholesterol reduction of 30%+.

In nature, small quantities of plant sterols can be found in a range of foods, particularly vegetable oils. The average plant sterol intake is about 250 milligrams. Vegetarians consume in a range of 400 to 750 milligrams. Plant sterol intake in traditional diets has been estimated to be about 1g (1000mg). Medical studies have concluded that 2-3g (2000-3000mg) effectively lower cholesterol. Fortified foods or supplements are typically required to obtain these levels.

Click for Chart of Foods with Plant Sterols

kardea - gourmet nutrition for cholesterol management

Omega-3s & Heart Health: Strong Science Supports Broad Recommendations

2008-12-16T08:53:00.006-05:00

Broad medical recommendations, like those now advanced by the American Heart Association (AHA) and National Cholesterol Education Program, come only after extensive research has confirmed usefulness. Multiple types of research are used. Epidemiologic studies compare the difference in disease and diet across groups of people. Experimental studies assess the role of a nutrient or medication in laboratory animals. Clinical studies assess the impact when given to a test group of people. This impact is compared to a “control” group not taking the nutrient or medicine.

Omega-3s from fish oils have been subject to all types of studies, and the benefits associated with cardiovascular health and disease prevention have been consistently shown. As a result, leading medical organizations now recommend Omega-3s from fish oil for cardiovascular health. The recommendations include:

500mg/day of Omega-3s from fish oil for adults that have not been diagnosed with coronary artery disease.

1000mg (1g)/day for adults that have been shown to have coronary artery disease.

3000mg-4000mg (3-4g)/ day for adults with highly elevated triglycerides.

Omega-3s are not associated with reductions in LDL (bad) cholesterol levels. Yet, cholesterol alone is only part of the cause of heart disease. A number of other factors can determine the damage that cholesterol can do. Omega-3s appear to favorably affect these factors including decreased blood pressure, reduced inflammation that leads to plaque formation, and the stabilization of existing plaque.

How significant is the impact on Omega-3s? Studies have indicated as much as a 18-20% reduction in a cardiovascular event such as a heart attack for healthy adult. For those with a history of heart disease, the impact has been shown at least as significant, and perhaps higher.

Omega-3s from fish oil represent an important component of an integrated and comprehensive nutritional approach to cardiovascular health. Other broad recommendations include the consumption of 10+ grams/day of selected soluble fibers such as those from oats, beans, barley and psyllium, 2 grams/day of plant sterols, and diet that restricts saturated fats, trans fats and dietary cholesterol. Click here for more information on nutritional and natural cholesterol management.

Link to report on Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease in Circulation Journal of the American Heart Association, 2002.

Cardiovascular Disease Prevention: Between Healthy Habits and Prescription Medications

2008-12-04T08:19:00.013-05:00

With cardiovascular disease the largest cause of death and disability in the United States, the scientific community continues intense investigations into approaches for prevention. In the New England Journal of Medicine, Doctor Mark Hlatky of Stamford University School of Medicine, writes, "The aphorism 'prevention is better than cure' makes perfect sense when applied to healthy habits such as following a sensible diet, maintaining an ideal body weight, exercising regularly, and not smoking. But increasingly, prevention of cardiovascular disease includes drug therapy, particularly statins to lower cholesterol levels."

In this editorial, Dr. Hlatky is reponding to the growing interest in prescribing cholesterol-lowering medications to a much larger segment of the American population---including those with cholesterol levels well below the risk standards established by the National Cholesterol Education Program of the National Institutes of Health. These medications already are the single largest class of drugs sold in the U.S. today, exceeding $30 billion/year.

There is mounting evidence that lowering LDL cholesterol below the NCEP risk-adjusted standards is reducing the incidence of cardiovascular events such as heart attack and strokes. Further, recent studies, notably the JUPITER study published in the New England Journal of Medicine, reinforces the evidence that statin medications not only favorably alters cholesterol levels but also reduce the level of inflammation in the arteries. In addressing inflammation, the medication may reduce a root cause of arterial plaque development.

Yet, what remains lost in the discussions between healthy habits and drug treatment is the positive, therapeutic power of nutrition. Nutritional solutions extends beyond the restriction of saturated fats, trans fats and cholesterol to nutrients that actively improve cholesterol levels and reduce inflammation. For many, these nutritional tools can allow the individual to achieve target cholesterol levels and serve as an effective statin alternative. For others, the nutritional approach offers an opportunity for reductions in the dosages and number of medications required to achieve heart healthy targets.

The tragedy: compared with the funding for pharmaceutical studies, an incredible small amount of money is being spent to advance the nutritional science. With few major studies reporting on the benefits of nutritional cholesterol management, the news media reports on the pharmaceutical studies. The extensive and widely reviewed understanding of the nutritional solution is then overshadowed.

Here at Kardea, we are working to provide you with both the knowledge and the natural products that advance heart health. We are only one source. For others, discuss with your medical providers. Also, check out our the resource page on the Kardea Nutrition website or for great recipes for cholesterol management, click over to Kardea Gourmet .

Another good source of information: http://cholesterol.about.com/od/treatments/u/Treatments.htm

Kardea Nutrition, Heart Healthy & Inspired.

Bloggers Taste Test Kardea Nutrition Bars

2008-09-24T15:04:00.020-04:00

Yep, we are a mission-driven start-up with a love and a passion for what we do. Delivering plant sterols and soluble fiber for cholesterol management, the bars also deliver wonder aromas, great tastes and satisfying texture and finish. Here is what some bloggers are saying about the Kardea Gourmet Nutrition Bars:

Mark at Hangry Pants
Unlike some other bars I have eaten in this category, eating one gave me the feeling that Kardea bars are made with love ...

Vicky at Frenchy Addict
Yes, I love the Kardea bar "almost" as much as I love my beloved Larabar. Check your health food markets to see if they're available in your neck of the woods. I encourage you to try them, they're moist and chewy. ...

Caoline at Eat, Pray, Run
Try This Bar!! So, y’all know that I am a devout Larabar lover. But I just have to introduce to you this bar that I had the opportunity to try this weekend. This Kardea Nutrition Bar was sent to me last week from founder Rob Leighton. I had one of these babies pre-workout on Friday, and I have got to tell you — it is YUMMY, YUMMY, YUMMY! I went in with the intention of eating just half, but ended up gobbling the whole thing down!

Abby at Eat, Drink and Be Aware
Lemon Ginger- We loved the lemon ginger! The texture is a little more hearty than Larabars and the taste combination is out of the world good! Does anyone ever buy those Carr's English Ginger Lemon Creme Cookies at the store? ...
Banana Nut- first words out of Emmet's mouth was Wow! "I like the taste and texture- tastes like Banana Bread"- we all like the texture of these bars. They look like caramel and are moist and chewy but have a little nibble to them as well.Cranberry Almond- extremely fresh tasting. I can't seem to put my finger on it but this bar reminds me of something.... something good. The one thing that I come back to is the flavorings-- they all taste really fresh and are not overpowering.

Heather at Hangry Pants
Delicious! I love lemon flavor…the best way I can describe it is “gentle… I was pleasantly surprised when I bit into it and it had some chew, but was still soft. I looked more closely at the ingredients and realized it must be the rolled oats I am loving in there…

Juilet at Daily Eats
Well, in the case of Kardea Nutrition, food not only tastes good, but it’s also very good for you. Kardea’s snack bars deliver 50% more heart healthy soluble fiber than found in oatmeal, and each provides 1 gram of cholesterol lowering ...

Tina at Carrots 'N' Cake
The Chai Spice Kardea Bar had an amazing chai aroma, which hit me as soon as I opened the package. The flavor of the bar was equally wonderful-- nice and strong...

Rose at On a Lobster Placemat
I am certainly going to add Kardea bars to my shopping list. They feel like a good alternative to Larabars and Clif Bars, which I eat on a regular basis. It would probably be good to have something with a little less fat and calories ...

Sammie at Running with a Recipe
I had a Lemon Ginger Kardea bar - these bars are really becoming a favorite of mine. This was the 3rd flavor that I have tried and I love them all. The flavor was delicious …

As our sampling budget allows, we will send out more products for review. Interested. Email us at customerservice@kardeanutrition.com.

Cholesterol Education Month A Good Time to Consider Statin Alternatives

2008-09-18T09:06:00.002-04:00

September is National Cholesterol Education Month.

The stakes are high. Cardiovascular disease remains the leading cause of death and morbidity in the U.S. Cholesterol management is a leading focus for disease prevention. Sales of related medications now exceed $30 billion in annual sales.

With a passion for natural health, we know well that therapeutic nutrition---based on balanced diets incorporating good fats, viscous soluble fiber, plant sterols and selected other nutrients---can achieve significant improvements in blood lipid profiles. We can lower LDL (bad) cholesterol and triglycerides. We can raise HDL (good) cholesterol. We can reduce the inflammation that trigger arterial plaque development.

The science is more than solid. It is endorsed by the National Institutes of Health, the American College of Cardiology and the American Heart Association. The FDA endorses health claims associated with these nutritents. Overall, therapeutic nutrition can deliver results comparable to many cholesterol-lowering medications.

Yet, the new Lipitor ad campaign eclipses any public education promoting the natural alternatives.

We certainly are not opposed to the medical solution, but as a matter of public policy, our society would be far better served by an extensive therapeutic nutrition campaign than by the Pharma consumer campaigns.

Perhaps we should insist on equal time---for every dollar Big Pharma spends to promote a cholesterol-lowering medication, it should be required to spend an equivalent amount on a separate therapeutic nutrition campaign. In the meantime, raising consumer awareness remains an important function of the natural and health food retailers, and the nutritional health professionals.

Kardea Nutrition--hearty health and inspired---enabling natural cholesterol management.

Kardea Celebrates National Cholesterol Education Month

2008-09-16T10:31:00.003-04:00

See Special Offer Below

September is National Cholesterol Education Month, a good time to get your blood cholesterol checked and take steps to lower it if it is high. National Cholesterol Education Month is also a good time to learn about lipid profiles and about food and lifestyle choices that help you reach personal cholesterol goals.

High blood cholesterol affects over 65 million Americans. It is a serious condition that increases your risk for heart disease. The higher your cholesterol level, the greater the risk. You can have high cholesterol and not know it. Lowering cholesterol levels that are too high lessens your risk for developing heart disease and reduces the chance of having a heart attack or dying of heart disease.

The National Heart, Lung, and Blood Institute offers helpful resources to use during National Cholesterol Education .

In celebration, Kardea is offering online discounts on its wellness bars (20% off ) and fortified oils (40% off), both formulated to enable natural cholesterol management. Free shipping also is available this month for orders over $49.00. Sign-up for our newsletter and receive and an additional celebratory coupon for further discounts.

Cholesterol Management: Beyond Disease Prevention

2008-09-01T12:42:00.005-04:00

The guidelines of the National Cholesterol Education Program define LDL cholesterol below 100mg/dl as optimal for otherwise healthy people. Yet, as a matter of disease prevention, these same guidelines suggest that substantially higher levels of LDL cholesterol may be acceptable. These standards are used as a baseline for determining the appropriateness of cholesterol-lowering medications.

Many doctors also are well aware that the non-optimal LDL standards are only a baseline. These doctors are apt to prescribe a cholesterol-lowering medication to achieve the more optimal level.

Here at Kardea, we look to natural cholesterol management to achieve the more optimal levels. Yes, medications may be needed by some, but a nutritional approach has proven as potent as many pharmaceutical therapies. And we recognize that cholesterol management extends well beyond simply lowering LDLs. Our prior blog posts and the numerous links and articles found on our resources page explore this more comprehensive approach.

The important point: cholesterol management is consistent with good health, not simply disease prevention. Whatever your currents levels ---- even if you believe that your cholesterol is not at risky levels ---- consider the benefits of pursuing a more integrated and comprehensive approach.

Turning 50 with a Focus on Vitality Not Disease Prevention

2008-08-30T15:32:00.023-04:00

I turned 50 this past June. I am told that 50 is not old. I am told that 50 is the new 40, or perhaps 35. I am a believer. I do not think like I am old. I remain eager to learn anew.

Yet, I have acquired a gnawing sense that time is bracketed, not limitless. The weekly mailings from the AARP provide the reminder. The challenges faced by my 85 year old parents sharpen the feelings. Neither is ravaged by a particular disease. Time, slowly but with increasing speed, erodes their vitality.

With an eye not only looking to disease prevention, but also towards extending my years of vitality, I approach a health consciousness. Overall, I believe that maintaining a healthy cardiovascular system is a key to extending vitality.

I exercise, but perhaps not with the intensity to optimize my cardiovascular health. The hip pains and lower back aches serve as a bit of an obstacle.

I watch my weight, but it still falls somewhere above the ideal range, although I am not defined as overweight.

I am perhaps most successful with assuring that I eat the right foods---balanced, high in fruits, vegetables, good fats (monounsaturated fats) and good carbs (whole grains and fibers), and enhanced with certain cholesterol-managing nutrients, notably plant sterols, viscous fibers, omega-3s and selected types of niacin. No doubt, my success here lies with the pleasure I derive from food shopping, gourmet cooking and social eating.

Natural Cholesterol Management: Looking Beyond Heart Disease Prevention

Many doctors also are well aware that the non-optimal LDL standards are only a baseline. These doctors are apt to prescribe a cholesterol-lowering medication to achieve the more optimal level.

Here at Kardea, we look to natural cholesterol management to achieve the more optimal levels. Yes, medications may be needed by some, but a nutritional approach has proven as potent as many pharmaceutical therapies. And we recognize that cholesterol management extends well beyond simply lowering LDLs. Our prior blog posts and the numerous links and articles found on our resources page explore this more comprehensive approach.

The important point: cholesterol management is consistent with good health, not simply disease prevention. Whatever your currents levels ---- even if you believe that your cholesterol is not at risky levels ---- consider the benefits of pursuing a more integrated and comprehensive approach.

Intermediate Dose Niacin and Natural Cholesterol Management

2008-08-16T11:07:00.016-04:00

Niacin, also known as Vitamin B3, is vital for good health. Niacin helps convert food into energy, build red blood cell counts, and synthesize hormones.

For basic good health, a relatively small amount of niacin, about 20mg/day, is needed. Americans typically obtain this level from a balanced, healthy diet. Our bodies also can manufacture niacin.

At substantially higher levels—1000-2500mg/day--- a specific type of niacin significantly improves cholesterol levels. Niacin as nicotinic acid can lower LDL cholesterol by up to 25%, raise HDL cholesterol by as much as 35%, and lower triglyceride levels by 20% to 50%.[i] The medical community[ii] generally defines these high dosages as a drug that should be taken under a physician’s care. The primary concerns relate to potential liver complications. A doctor will monitor liver function as part of a routine blood test. As a practical matter, the very real and sometimes intense flushing side-effects associated with nicotinic acid at these levels may make a “buffered” prescription nicotinic acid the only viable option.

Nonetheless, nicotinic acid supplements are approved for sale by the Food and Drug Administration. Further, the intake of niacin at intermediate dosage levels --- 100-1000mg/day---has been shown to significantly improve the levels of both HDLs and triglycerides. Coupled with other elements of natural cholesterol management, intermediate dosage of niacin in the form of supplements may provide a meaningful contribution in long term cardiovascular health.

Cholesterols Management: Beyond LDL Reduction

LDL cholesterol reduction has been the primary focus of the medical and pharmaceutical community. This focus is supported by the significant and extensive research confirming the positive health effects of lowered LDL, including reduced heart attacks, strokes and other cardiovascular diseases.

Increasingly, medical science recognizes that LDL reduction alone is only part of cholesterol management and cardiovascular health and wellness.

Researchers are assessing the composition of cholesterol and triglycerides in our blood. For instance, the NIHs’ National Cholesterol Education Program (NCEP) reports that “strong epidemiological evidence links low levels of serum HDL cholesterol to increased CHD (coronary heart disease). High HDL-cholesterol conversely conveys reduced risk.”[iii] The NCEP identifies having HDLs less than 40mg/dl as a risk factor for heart disease. Levels above 60mg/dl are associated with a reduced risk of heart disease.

Statins, the leading medication for LDL reduction, have been associated with some HDL increases. Yet, under the NCEP guidelines, statins are typically recommended only when LDL levels are elevated.

Low HDL levels without elevated LDL levels are nonetheless fairly common. Up to 50% of patients not typically candidates for LDL-lowering medications have low levels of HDLs. In patients with premature coronary artery disease, low HDL levels are the most common abnormality in blood lipids.[iv]

A number of recent studies indicate that small increases in HDLs can significantly reduce the incidence of cardiovascular-related death. A 1mg/dl increase in HDL has been associated with a 2%-3% reduction in coronary artery disease.[v] Another extensive study concluded that increasing HDLs by 6% in patients with low HDL cholesterol decreased heart-related deaths and non-fatal heart attacks by 22%.[vi]

Intermediate Daily Dosages of Niacin as Nicotinic Acid

Between the 20mg recommended for basic health and the 100x greater levels used to manage at-risk patients lies a potential role for niacin for promoting cardiovascular health. In one study, patients took 50mg of niacin as nicotinic acid twice per day for 3 months. The patients on the niacin experienced an average 5% increase in HDLs, or an average of 2.1mg/dl.[vii] In another study, 500mg/day of niacin as nicotinic acid raised HDLs by 10% (close to 5mg/dl) and lowered LDLs by 5% and Triglycerides by 5%.[viii] At 1000mg/day, improvements were 15%, 7% and 11% for HDL, LDL and triglycerides respectively.

The medical community has refrained from endorsing the use of nicotinic acid supplements at these dosage levels as part of a more natural, statin-free solution to blood lipid management. The medical community’s reticence flows, in part, from doctors’ distrust of nutritional supplements. Supplements are subject to fewer regulations than pharmaceuticals, but the industry also is not without regulatory requirements, and many high quality and reliable supplement manufacturers and retailers exist.

Another issue surrounding niacin relates to the potential for consumer confusion. There are three types of niacin available---nicotinic acid, niacinamide, inositol hexanicotinate. Only nicotinic acid has been shown to be effective for cholesterol management.

Further, there are three forms of nicotinic acid—immediate release, sustained release and extended release.

Immediate release nicotinic acid often causes a very uncomfortable flushing of the skin accompanied by an intense feeling of heat, tingling and itching---even at relatively low levels of niacin. The flushing can start a few minutes or a few hours after taking niacin. Flushing typically subsides within 30 minutes, often much sooner.

At the intermediate dosage levels, flushing can be managed by gradually increasing the levels of nicotinic acid. You can start by trying 50mg with lunch and dinner. As your body grows accustomed to these levels, you can try raising your niacin intake with these meals. You might also try taking nicotinic acid before bed.

For individuals who cannot overcome the flush or for those looking to move to higher a dosage level, nicotinic acid is sold as a supplement in a sustained release version. The sustained releases version reduces the intensity of flushing, but at higher levels, it has been associated with liver damage.

The third form of nicotinic acid, extended release niacin, is available as a prescription. This form has typically been used at high level and only to treat harmful cholesterol levels that cannot be remedied through nutrition, certain lifestyle changes and statins.

Integrating Niacin into Natural Cholesterol Management

Intermediate doses of niacin as nicotinic acid may be meaningful for raising HDL cholesterol for cardiovascular health promotion, since the corresponding 5-10% increase in HDLs can significantly lower the risk of heart attack. The impact at these dosage levels alone may fall short of achieving more optimal cholesterol and triglyceride levels. When coupled with other nutrients, however, these niacin dosages may enable an individual to achieve optimal targets. Substantial LDL reductions can be further achieved through the restricted intakes of saturated and trans fats, higher intakes of monounsaturated fats, and therapeutic levels of plant sterols and selected types of fibers (including soluble fiber from oats, barley, psyllium, beans and certain fruits) .[ix] While Omega-3s have not been proven to lower LDL cholesterol, they lower triglycerides and may positively alter other factors leading to the build-up of arterial plaque. Modest weight loss and increased physical activity can further raise HDLs.

With many Americans suffering from the side-effects of statins and others preferring to minimize a lifetime of prescription drugs, it seems appropriate for the medical community to take a greater interest in the role of intermediate dosages of niacin, particularly as a component of broader therapeutic nutrition efforts.
_________________________
[i] Anne Goldberg, M.D. et al, Multiple-Dose Efficacy and Safety of an Extended-Release Form of Niacin in the Management of Hyperlipidemia. The American Journal of Cardiology, Vol. 85, pp 1100-1105 May 1, 2000.

[ii] Detection, Evaluation & Treatment of High Blood Cholesterol in Adults, Third Report of the National Cholesterol Education Program Expert Panel National Institute of Heart, Lung and Blood Institute, National Institutes of Health, September 2002. www.nhlbi.nih.gov/guidelines/cholesterol/atp3full.pdf

[iii] Ibid ”II Rational for Intervention”.

[iv] Ibid.

[v] DJ Gordon et al., High Density Lipoprotein Cholesterol and Disease: Four Prospective American Studies, Circulation 1989

[vi] HB Robins et al., Gemfibrozil for the Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol, The New England Journal of Medicine 1999.

[vii] Jennifer Wink, MD et al., Effect of Very-Low-dose Niacin on High-Density Lipoprotein in Patients Undergoing Long-Term Statin Therapy, American Heart Journal, Volume 143, Number 3, March 2002.

[viii] Goldberg Op Cite, p1102

[ix] Ibid

Statins for Our Kids?

2008-07-23T11:41:00.006-04:00

The American Academy of Pediatrics is recommending wider cholesterol screening for children. Underpinning these recommendations is the understanding that elevated LDL (bad) cholesterol in kids can lead to an onset of cardiovascular disease earlier in adulthood. It recognizes that the plaque in an adult's arteries may have begun developing very early in life.

The recommendations call for cholesterol screening of children and adolescents, starting as early as the age of 2 and no later than the age of 10, if they come from families with a history of high cholesterol or heart attacks before 55 for men and 65for women.

Screening is also recommended for children when family history is unknown, or if they have other risk factors, like being at or above the 85th percentile for weight, or have diabetes. If the child’s cholesterol level is normal, retesting is suggested in three to five years.

The report also suggests that for a selected group of children, prescribing a statin medication might be appropriate. Drug treatment, according to these recommendations, should be considered for children 8 and older who have very elevated LDLs, or when family history or weight indicate multiple risk factors for developing heart disease.

Not surprisingly, these recommendations raised an outcry.

“When you have a kid whose cholesterol looks like an overweight 65-year-old, what do you do?” asks Dr. David Ludwig, director of the childhood obesity program at Children’s Hospital in Boston and quoted in The New York Times. In developing the recommendations, we "had to balance the risks of treating children with powerful drugs, about which there is limited long-term data, with the risks of not treating children with unprecedented cardiovascular disease risk factors.”

Dr Ludwig also is reflective about these recommendations. Quoted in the Times, he comments “my concern is what this is saying about society when we are so quick to prescribe drugs for these conditions before having systematically attacked the problem from the public health perspective”.

For many, the systematic solution focuses on addressing childhood obesity. No doubt, an extraordinarily important challenge in its own right. Yet, cholesterol management in children go beyond issues associated with obesity. Elevated cholesterol can be found in otherwise fit and thin adults and children alike.

Between weight loss and medication lies therapeutic nutrition as outlined by the National Cholesterol Education Program (NCEP) of the National Institutes of Health. Eating a balanced diet that replaces saturated fats and trans fats with monounsaturated fats (e.g. fats in olive oil, nut butters), adds high levels of soluble fiber from oats, beans, high-pectin fruits, and psyllium) and adds plant sterols can significantly improve cholesterol and blood lipid profiles. Other nutrients, including Omega-3s from fish oils, also have been found useful.

The NCEP asserts that therapeutic lifestyle changes with a particular emphasis on what we eat (not simply how much we eat) can deliver results comparable to many cholesterol-lowering medications. For links to the NCEP reports, clinical research and other educational materials advancing natural cholesterol management: Kardea Nutrition http://www.kardeanutrition.com/. For recipes: http://www.kardeagourmet.com/

Red Yeast Rice: Statin Alternative or Natural Statin

2008-07-23T11:20:00.006-04:00

A study recently published in the Mayo Clinic Proceeding has confirmed the power of natural alternatives for cholesterol management. The study, authored by group of doctors and researchers associated with University of Pennsylvania, found that a combination of the Therapeutic Lifestyle Changes (TLC) recommended by the National Cholesterol Education Program (NCEP) of the National Institutes of Health coupled with red yeast rice and fish oil supplements led to a more substantial reduction in LDL (bad) cholesterol than did simvastatin, a statin medication sold by Merck Drug under the brand name Zocor.

The authors wrote “our study was designed to test a comprehensive and holistic approach to lipid lowering…. These results are intriguing and show a potential benefit of an alternative, or naturopathic, approach to a common medical condition, hyperlipidemia”

Statin Alternative or Natural Statin

The media reported the study as an “alternative to statins.” In reality, the choice is between a prescription, controlled statin and a natural source of statins. The active ingredient in red yeast rice supplements is a naturally occurring statin. It is chemically similar to the prescription lovastatin sold by Merck under the brand name of Mevacor. In short, red yeast rice does not represent a statin alternative, but rather a natural source of statins.

For those of us with a predisposition to natural products, this may seem like an intriguing option, but red yeast rice supplements face some important challenges. The authors of this study outlined the issues:
• In 2001, the US Food and Drug Administration determined that red yeast rice with a controlled level of the lovastatin was a drug, not a dietary supplement.
• As a result, the supplement manufacturer cannot control or test for the active compounds in red yeast rice supplement. While the chemical composition of the red yeast rice supplement used in the study was known and controlled, the composition of various products and the batch consistency between lots from the same source make recommending red yest rice supplements difficult.
• Taking red yeast rice without a physician’s supervision could also have unknown risks. The lovastatin component can cause the same side effects as any statin, and a potentially dangerous metabolite, citrinin, can form in poorly manufactured preparations.

Statin Alternative Do Exist

The American Heart Association, the American College of Cardiology, the American College of Preventive Medicine and many other health and medical organization participated in developing the NCEP recommendations. The recommendations emphasize that “many people will be able to lower their LDL enough” with lifestyle and nutritional changes alone. The NCEP reports that “if your LDL needs more lowering, you may have to take a cholesterol-lowering drug” in addition to the lifestyle changes . “However, by staying on the TLC Program, you’ll be keeping that drug at the lowest possible dose. “

The Kardea website provides an extensive amount of information about TLC. It also addresses some of the nutrients not specifically recommended by the NCEP, but widely reviewed by the medical community. The important point: before taking a statin----from a prescription or an herbal supplement---consider your alternatives.

Foods with Plant Sterols

2008-06-24T15:35:00.004-04:00

In nature, small quantities of plant sterols can be found in a range of foods, particularly vegetable oils. In the American diet, the average plant sterol intake is about 250 milligrams. Vegetarians consume in a range of 400 to 750 milligrams. Plant sterol intake in traditional diets has been estimated to be about 1g (1000mg). Medical studies have concluded that 2-3g (2000-3000mg) effectively lower cholesterol. Fortified foods or supplements are typically required to obtain these levels.

At our sister site, Kardea Gourmet, you can find a listing of a variety of foods with plant sterols --- naturally-occurring and fortified. You also can find (and contribute) great recipes for foods that actively work to improve cholesterol levels.

Father's Day Gourmet & Cholesterol Management

2008-06-13T21:16:00.009-04:00

The science is clear and convincing. Therapeutic nutrition---that incorporates 2g of plant sterols, over 10g of soluble fiber, monounsaturated fats replacing saturated and trans fats, and reduced animal sources of protein-- can achieve cholesterol reductions comparable to many of the widely prescribed medications.

With my daughter, we have created a delicious, natural, cholesterol-lowering Father’s Day menu.

We recommend recipes for lunch, a snack and dinner. With a single serving of each dish, you will enjoy:

2g of natural plant sterols from foods and taken through the course of the day.
30g of total fiber
7 grams of heart healthy soluble fiber.
1g Omega-3 fatty acids (EPA/DHA)
Only 150mg of dietary cholesterol (from the chicken and salmon)
Saturated fat is below 7 percent of total calories.
Monounsaturated fats equal about 23% of total calories.

Overall, we are nearly in-line with the recommendations of the National Cholesterol Education Program, but we fall a bit short on the heart healthy soluble fiber.

So look to breakfast to finish your therapy. Here are some simple guidelines. A good morning start would be an oat cereal and fruit. If you are looking for something a bit more interesting, there are a number of oat pancake recipes that can be found online. Stay away from the ones with butter and lots of eggs in the ingredients. Either way, you should get you to the 10g minimum recommendations for soluble fiber.

In my life, I actually shoot for the higher, 20-25g recommendation. The only way I have been able to achieve this goal is with psyllium husk or concentrated oat bran. I dissolve a tablespoon of one of these fibers into my morning juice. A heaping tablespoon of the psyllium husk, for instance, delivers 9g of heart health soluble fiber. Most people can tolerate such a dosage, but it is probably something you need to work up to.

The Menu

Luncheon
Mediterranean Salmon Salad
Chick Peas with Oregano
Roasted Asparagus
Whole Grain Bread or Whole Wheat Roll

Snack
Kardea Gourmet Nutrition Bar with 1g plant sterols, 7g fiber, and 7g protein.

Dinner
1st Course
Gazpacho: Quick, Bold & Delicious

2nd Course
Chicken Balsamic Reduction
Steamed Broccoli
Barley Pilaf

Dessert
Sorbet of Your Choosing
Fresh Berries or Sliced Ripe Peaches.

WebMD Addresses Natural Cholesterol Management

2008-06-12T14:46:00.009-04:00

WebMD has recently released an online video addressing natural cholesterol management. View Video.

In the accompanying artcle, WebMD reports, "To lower your cholesterol, ...a handful of some "functional foods" have been shown to make a big impact on your cholesterol levels."

"These foods may not be magic, but they're close to it," says Ruth Frechman, RD, a spokeswoman for the American Dietetic Association quoted in the WebMD article.

The article continues that "studies have shown that a diet combining these "superfoods" may work as well as some cholesterol-lowering medicines to reduce your "bad" LDL cholesterol levels." This is great news for the 105 million adults in the U.S. with high cholesterol, particularly for the many people that can't handle the side effects from cholesterol drugs.

The Kardea website provides an excellent overview of how these key nutritions fit into a heart health diet. And for recipes enabling therapeutic nutrition for cholesterol management, click to Kardea Gourmet.

WFSB Better Connecticut Television Appearence

2008-05-20T10:07:00.002-04:00

As seen on Better Connecticut on CBS-affiliate WFSB, Rob Leighton, founder and chief executive officer of Kardea Nutrition, LLC explains the new system of natural foods and quality supplements that help people easily follow a diet that can significantly improve their cholesterol levels without prescription medications. Leighton also explains his personal mission to lower his cholesterol naturally.

Plant Sterols: What Are They? How Do They Work?

2008-05-20T09:15:00.012-04:00

Plants produce plant sterols. Animals produce cholesterol. Structurally similar, both bind to sites in our intestines where the cholesterol produced in our livers and consumed in our foods are absorbed into our blood.

Yet, our bodies have evolved the ability to distinguish between these types of sterols. On average, we absorb about 55% of cholesterol and less than 1% of the plant sterols. Plant sterols work to lower cholesterol by filling the "absorption gateways," thus blocking the cholesterol from entering the blood stream. Blocked cholesterol is execreted along with most of the plant sterols.

In nature, small quantities of plant sterols can be found in a range of foods, particularly vegetable oils (sources of plant sterols). The average plant sterol intake in the U.S. is about 250 milligrams. Vegetarians consume in a range of 400 to 750 milligrams. Plant sterol intake in traditional diets has been estimated to be about 1g (1000mg). Medical studies have concluded that 2-3g (2000-3000mg) effectively lower cholesterol. Fortified foods are typically required to obtain these levels.

The effectiveness of plant sterols will vary from person-to-person. Many people absorb cholesterol more effectively than others. For these individuals, the impact of plant sterols may be more significant.

Overall, plant sterols are an important component of a nutritional system designed to promote healthier cholesterol and blood lipid levels. Achieving maximum benefits from natural cholesterol management may require other nutrients---including the soluble fibers found in oats, beans, fruit and psyllium, certain types of niacin, Omega-3s, monounsaturated fats in place of saturated fats----all in the context of balanced nutrition, calorie-mindfulness and physcial activity.

Protein & Cholesterol Management: NCEP Discussion

2008-05-08T20:52:00.002-04:00

In our recent posts, we have provided you with the summary evidence and recommendations from the National Cholesterol Education Program as it relates to the consumption of fats--both good and bad, carbohydrates and certain key nutrients like plant sterols and soluble fiber. In regard to proteins, the National Cholesterol Education Program provides somewhat weaker recommendations. The NCEP recent report states:

"Dietary protein in general has little effect on serum LDL cholesterol level or other lipoprotein fractions. However, substituting soy protein for animal protein has been reported to lower LDL cholesterol. Plant sources of protein are predominantly legumes, dry beans, nuts, and, to a lesser extent, grann products and vegetables, which are lower in saturated fats and cholesterol. Animal sources of protein that are lower in saturated fat and cholesterol include fat-free and low-fat dairy products, egg whites, fish, skinless poultry, and lean meats."

The report continues noting that "Since there are inconsistent findings regarding both the dose and potential benefit of soy protein, soy protein's major role in LDL-lowering may be to help reduce the intake of animal food products with the higher content of saturated fatty acids."

NCEP Evidence Statement: High intakes of soy protein can cause small sreductions in LDL cholesterol levels, especially when it replaces animal food products (Stength of Evidence: A2, B2).

NCEP Recommendation: Food sources containing soy protein are acceptable replacements for animal food products containing animal fats.

Carbs, Proteins & Fats: The NCEP Balance

Carbohydrate: 50-60% of Total Calories* **

Dietary Fiber: 20-30 grams per day (10-25grams from Soluble Fiber)

Protein: 15% of Total Calories
Total Fat: 25-35% of Total Calories*
Monunsaturated Fat: Up to 20% of Total Calories
Polyunsaturated Fat: Up to 10% of Total Calories
Saturated Fat: Less than 7% of Total Calories
Dietary Cholesterol: Less than 200mg/day.

*Allows an increase of total fat to 35% of total calories and reduction in carbohydrate to 50% for persons with the metabolic syndrome. Any increase in fat intake should be in the form of either polyunsaturated or monounsaturated fat. **Carbohydrate should derive perdominantly from foods rich in complex carbohydrates including grains--especially whole grains---fruits, and vegetables.

Carbohydrates & Cholesterol: Recommendations from the National Cholesterol Education Program

2008-05-07T09:35:00.004-04:00

NCEP Evidence Statement: When carbohydrate is substituted for saturated fatty acids, LDL cholesterol levels fall (Strength of Evidence: A2, B2). However, very high intakes of carbohydrates (greater than 60 percent of total calories) are accompanied by a reduction in HDL cholesterol and a rise in triglyceride (B1, C1). The latter responses are sometimes reduced when carbohydrate is consumed with viscous fiber (C2); however, it has not been demonstrated convincingly that viscous fiber can fully negate the triglyceride-raising or HDL-lowering actions of very high intakes of carbohydrates.

NCEP Recommendations: Carbohydrate intakes should be limited to 60 percent of total calories. Lower intakes (e.g. 50% of calories) should be considered for persons with the metabolic syndrome who have elevated triglyceride or low HDL cholesterol. Regardless of intakes, most of the carbohydrate intake should come from grain products, especially whole grains, vegetables, fruits, and fat-free or low-fat dairy products.

Macronutrient NCEP Dietary Recommendations

Carbohydrate: 50-60% of Total Calories* **

Protein: 15% of Total Calories

Total Fat: 25-35% of Total Calories*

Monunsaturated Fat: Up to 20% of Total Calories

Polyunsaturated Fat: Up to 10% of Total Calories

Saturated Fat: Less than 7% of Total Calories

Dietary Cholesterol: Less than 200mg/day.

*Allows an increase of total fat to 35% of total calories and reduction in carbohydrate to 50% for persons with the metabolic syndrome. Any increase in fat intake should be in the form of either polyunsaturated or monounsaturated fat.
**Carbohydrate should derive perdominantly from foods rich in complex carbohydrates including grains--especially whole grains---fruits, and vegetables.

Trans Fatty Acids: Recommendations of the National Cholesterol Education Program

2008-05-05T12:48:00.004-04:00

NCEP Evidence Statement: Trans fatty acids raise serum LDL cholesterol levels (Strength of Evidence: A2). Through this mechanism, higher intakes of trans fatty acids should increase risk for CHD (coronary heart diseases). Prospective studies support an association between higher intakes of trans fatty acids and CHD incidence (C2). However, trans fatty acids are not classified as saturated fatty acids, nor are they included in the quantititative recommendation for saturated fatty acid intake of less than 7 percent of calories in the TLC (therapeutic lifestyle changes) Diet.

NCEP Recommendation: Intakes of trans fatty acids should be kept low. The use of liquid vegetable oil, soft margarine, and trans fatty acid-free margarine are encouraged instead of butter, stick margarine and shortening.

NCEP Discussion: Substantial evidence from randomized clinical trials indicates that trans fatty acids raise LDL cholesterol levels, compared with unsaturated fatty acids. These stuides also show that when trans fatty acids are substituted for saturated fatty acids, HDL (good) cholesterol levels are lower.

Click recommendations on unsaturated fats, both monounsaturated and polyunsatured.

Total Dietary Fat: Recommendations of the National Cholesterol Education Program

2008-05-02T16:16:00.003-04:00

NCEP Evidence Statement: Unsaturated fatty acids do not raise LDL cholesterol concentrations when substituted for carbohydrates in the diet (Strength of Evidence: A2, B2).

NCEP Recommendation: It is not necesary to restrict total fat intake for the express purpose of reducing LDL cholesterol levels, provided saturated fatty acids are reduced to goal levels (less than 7% of daily calories).

NCEP Evidence Statement: The percent of total fat in the diet, independent of caloric intake, has not been documented to be related to body weight or risk for cancer in the general population. Short-term studies suggest that very high fat intakes (greater than 35% of calories) modify metabolism in ways that could promote obesity (C2). On the other hand, very high carbohydrate intakes (greater than 60% of calories) aggravate some of the lipid and non-lipid risk factors common in the metabolic syndrome (A2. B2, C2).

NCEP Recommendations: Dietary fat recommendations should emphasize reduction in saturated fatty acids. Further, for persons with lipid disorders or the metabolic syndrome, extremes of total fat intake--either high or low--should be avoided. In such persons, total fat intakes should range from 25-35 percent of calories. For some persons with metabolic syndrome, a total fat intake of 30-35 percent may reduce lipid and non-lipid risk factors.

Polyunsaturated Fatty Acids: Recommendations from the National Cholesterol Education Program

2008-05-01T20:49:00.007-04:00

NCEP Evidence: Linoleic acid*, a polyunsaturated fatty acid, reduces LDL cholesterol levels when substituted for saturated fatty acids in diets (Strength of Evidence: A1,B1). Polyunsaturated fatty acids can also cause a small reduction in HDL cholesterol when compared with monounsaturated fatty acids (B2). Controlled clinical trials indicate that substitution of polyunsatuarated fatty acids for saturated fatty acids reduces risk for CHD (coronary heart diseases) (A2,B2).

NCEP Recommendations: Polyunsaturated fatty acids are one form of unsaturated fatty acids that can replace saturated fat. Most polyunsaturated fatty acids should be derived from liquid vegetable oils, semi-liquid margarines, and other margarines low in trans fatty acids. Intakes of polyunsaturated fat can range up to 10 percent of total calories. (Note: recommendation for monounsaturated fatty acid is a higher at up to 20 percent of total calories).

*Linoleic acid is a colorless to straw-colored, polyunsaturated fatty acid that is liquid at room temperature and of the omega-6 series. Good sources of linoleic acid from vegetarian sources are sunflower oil, and safflower oil.

Viscous Soluble Fiber: Recommendations from the National Cholesterol Education Program

2008-04-30T09:37:00.004-04:00

NCEP Discussion (excerpt): Because of the favorable effects of viscous fiber (soluble fiber from oats, fruit pectins, guar, beans and psyllium) on LDL cholesterol levels, the NCEP recommends that the therapeutic diet be enriched by foods that provide at least 5-10 grams of viscous fiber daily (Source of Soluble Fiber Chart). Even higher intakes of 10-25 grams per day can be beneficial.

NCEP Evidence Statement: 5-10 grams of viscous fiber per day reduces LDL cholesterol levels by approximately 5 percent (Strength of Evidence: A2, B1).

NCEP Recommendation: The use of dietary sources of viscous fiber (soluble fiber from certain sources) is a therapeutic option to enhance LDL lowering.

Plant Sterols: Recommendations from the National Cholesterol Education Program

2008-04-29T17:58:00.004-04:00

NCEP Evidence Statement: Daily intakes of 2-3 grams per day of plant stanol/sterol esters will reduce cholesterol by 6-15 percent Strength of Evidence (A2, B1)

NCEP Recommendation: Plant stanol/sterol esters (2g/day) are a therapeutic option to enhance LDL cholesterol lowering.

National Cholesterol Education Program: Assessing the Science

2008-04-28T19:38:00.004-04:00

The National Cholesterol Education Program brings together the wisdom of many individuals and organizations* in the medical community to undertake an assessment of the available scientific evidence related to cholesterol management. The NCEP has developed a methodology to rate the strength of the available evidence and has issued an extensive set of recommendations. The evidence is defined in terms of two categories:

Type of Evidence
A Major randomized controlled clinical trials (RCTs)
B Smaller RCTs and meta-analyses of other clinical trials
C Observational and metabolic studies
D Clinical Experience

Strength of Evidence
1 Very Strong
2 Moderately strong evidence
3 Strong trend

I have posted this blog as a reference for future posts.

*Member organizations of the NCEP include National Heart, Lung & Blood Institute (NIH), American Academy of Family Physicians, American College of Cadiology, American College of Preventive Medicine, American Diabetes Association, American Dietetics Association, American Hospital Association, American Medication Association, American Red Cross, Association of Black Cardiologists, Food and Drug Administration, Centers for Disease Control, American Nurses Association.

Monounsaturated Fats: Recommendations from National Cholesterol Education Program

2008-04-28T19:18:00.004-04:00

NCEP Evidence Statement: Monounsaturated fatty acids lower LDL cholesterol relative to saturated fatty acids. Monunsaturated fatty acids do not lower HDL cholesterol nor raise triglycerides. Strength of Evidence: A1, B2

NCEP Evidence Statement: Dietary patterns that are rich in monounsaturated fatty acids provided by plant sources and rich in fruits, vegetables, and whole grains and low in saturated fatty acids are associated with decreased CHD (cardiac heart disease). However, the benefits of replacement of saturated fatty acids with monounsaturated fatty acids has not been adequately tested in controlled clinical trials. Strength of Evidence C1

NCEP Recommendations: Monounsaturated fatty acids are one form of unsaturated fatty acid that can replace saturated fatty acids. Intake of monounsaturated fatty acids can range up to 20 percent of total calories. Most monounsaturated fatty acids should be derived from vegetable sources, including plant oils and nuts.

NBC News Reports: Plant Sterols-A Natural, Safe & Easy Way to Lower Cholesterol

2008-04-09T19:56:00.006-04:00

Wednesday, April 8, 2008
Reported by: Joe Vignolo, Denise Nakano, NBC News

A natural, safe and easy way to lower cholesterol. It's been around forever, but chances are, it's one alternative medicine you have never heard of.

"Nowadays, it is no longer good enough to know your total cholesterol level. You really need to know your breakdown - the breakdown between the good and the bad," said cardiologist Dr. Daniel Rader. This is the bad stuff: too much LDL, or bad cholesterol, circulating in the blood. It builds up in the arteries, slowly narrowing them or forming clots. And that can lead to heart attack or stroke.

Medicine can help, "but, there are an awful lot of people who have cholesterol levels that are higher than they should be, but not so high that they really need medication," said Dr. Rader.

Diet and exercise work. And, Dr. Rader says, so can eating phyto or plant sterols, naturally found in fruits, vegetables, nuts and seeds, added to other foods like spreads and snack bars, or taken as a supplement.

"There's no question that phytosterols, or plant sterols, are one of the best proven - if you will - 'alternative' methods of lowering cholesterol, short of drug therapy," said Dr. Rader.

Dr. Rader is a specialist in preventive cardiac medicine. He is a strong believer in plant sterols for people with high cholesterol who don't yet show signs of heart disease. He says they have almost no side effects and are safe for children and teens.

Research finds they can reduce bad cholesterol by 10 to 15 percent. And you can use them in combination with cholesterol-lowering prescription drugs. "I've never had really serious cholesterol trouble, but each time I went to the doctor, she was warning me that it was inching up," said David Hollenberg, who tried plant sterols. Hollenberg says he has never been shy about alternative medicine and decided to give a plant sterols supplement a try. He doesn't know yet what impact they have had on his cholesterol, but he thinks it is worth a try.

"Plant sterols are one of the rare things in the alternative medicine world that actually have been studied, have been proven to work, and are actually endorsed by people like me: card-carrying, regular doctors who actually think that this really makes sense to do," said Dr. Rader.
If you decide to try plant sterols to lower your cholesterol, dose really matters. To be effective, you must take it every day and be sure you're getting enough. For example, one or two tablespoons of sterol-containing spread a day has what you need.

Kardea Nutrition foods with plant sterols.

Kardea Exhibiting at Dietetic Conferences

2008-04-09T08:40:00.004-04:00

As part of our ongoing efforts to work with those health professionals working directly with individuals seeking to improve their cardiovascular health through positive nutrition, Kardea will be exhibiting at the Food & Nutrition Conference & Expo , the national conference of the American Dietetic Association. The conference will be held in Chicago on October 25-28, 2008. In the Spring, 2008, we also will be presenting our system for natural cholesterol management at the Florida, New York, New Jersey, Connecticut and Massachusetts State Dietetic Conferences.

Zetia/Vytorin Study: A Perspective

2008-04-07T21:36:00.009-04:00

You may have heard the considerable debate regarding the cholesterol-lowering medication, Zetia. Unlike statins which affect your cholesterol production, this drug blocks the absorption of both dietary and biliary (liver-produced) cholesterol into the blood stream. The drug is intended to provide individuals who cannot reduce LDL cholesterol using diet and exercise with an alternative to high dosages of statin medications. It also was developed for those who simply cannot tolerate statins.

In a recent controversial study reported in the New England Journal of Medicine, the effects of taking Zetia and the statin, Zocor, combined (together known as the drug Vytorin) was compared to the effects of taking Zocor only.

Here are results:

The group taking the two drugs experienced an LDL cholesterol decline that was 27% greater than the Zocor-only group.

Despite the increased lowering of LDL cholesterol in the group that received both medications, both groups saw arterial plaque build at rate that was similar (although those on the combination drug saw a somewhat larger, but not statistically significant, increase).

This finding is at odds with our traditional understanding of the favorable relationship between lower LDL cholesterol and atherosclerosis.

The trial, however, did not directly address whether lowering of LDL cholesterol with the combination drug reduces heart attacks, strokes and other cardiovascular “events.” The combination drug may or may not provide an additional benefit.

So how is the medical community responding?

An editorial in the New England Journal of Medicine observes that “it seems prudent to encourage patients whose LDL cholesterol levels remain elevated despite treatment with an optimal dose of a statin to redouble their efforts at dietary control and regular exercise,” leaving Zetia for special situations. Yet, well trained, qualified doctors continue to prescribe the combination drug more broadly, believing that a single study does not unseat established wisdom.

The human body is profoundly complex, and we simply do not know with certainty how any particular approach will affect our long term health and longevity. We can only play the odds as we know them today. This requires that each of us take an educated approach to our health. Kardea aims to enable the members of its community to make more informed decisions about cholesterol management and natural nutrition.

Lowering Cholesterol: A Piece of the Heart Health Puzzle

2008-03-12T17:03:00.006-04:00

The relationship between LDL cholesterol and cardiovascular diseases has been well-documented and summarized by the NIH's National Cholesterol Education Program.

Epidemiologic studies (i.e. research that associates the lifestyles of different populations or groups to a disease), laboratory studies (i.e. research into the effects of certain nutrients or medication on cells outside the body) and clinical studies (research on the effects of certain nutrients or medications on a living person) all show that cholesterol is a critical factor in the development of atherosclerosis.

Atherosclerosis occurs when plaque builds up on the walls of your arteries. This plaque leads to a narrowing and ultimate closing of an artery. Plaque also can break free of the arterial wall. It then can lodge further down your artery, causing a blockage that can lead to a stroke, heart attack, or a blood clot in your arms, legs or other parts of your body.

National Cholesterol Education Program Summary of Research

Studies across different populations reveal that those with higher cholesterol levels have more arterial plaque and heart disease than those with lower levels. People who migrate from regions where average serum cholesterol in the general population is low to areas with high cholesterol levels show increases in their cholesterol levels as they acculturate. These higher levels in turn are accompanied by higher levels of heart disease.
Atherosclerosis often can be identified in adolescence or early adulthood. The cholesterol level in young adulthood predicts development of heart disease later in life. In three prospective studies with long-term follow-up, detection of elevated serum cholesterol in early adulthood predicted an increased incidence of heart disease in middle-age.
The power of elevated LDL to cause heart disease has been shown most clearly in persons with genetic forms of very high cholesterol. In these persons, advanced coronary atherosclerosis and premature heart disease occur commonly even in the complete absence of other risk factors. These disorders provide stronge evidence that LDL is a powerful cause.
Since LDL-cholesterol levels of less than 100 mg/dL throughout life are associated with a very low risk for heart disease in populations, they can be called optimal. Even when LDL-cholesterol concentrations are near optimal (100–129 mg/dL), plaque formation occurs; hence, such levels must also be called above optimal. At levels that are borderline high (130–159 mg/dL), plaque formation proceeds at a significant rate, whereas at levels that are high (160–189 mg/dL) and very high (above 189 mg/dL) it accelerates further.
A large number of clinical trials on cholesterol-lowering therapy have been carried out over the past four decades. The initial encouraging findings of earlier trials have recently been reinforced by the robust findings of a large number of studies.

The Research in Context: Only A Piece of the Puzzle

Lowering LDL cholesterol is not a guarantee of cardiovascular health. Many people on cholesterol-lowering medications still suffer heart attacks, strokes and other cardiovascular challenges. Similarly, LDL cholesterol levels above the "optimal" levels should not necessarily require an individual to proceed to a lifetime of cholesterol-lowering medications. Each of us should discuss this carefully with our medical providers.

In these conversations, however, you should recognize that cholesterol-lowering is only one piece of the puzzle. Some things to consider:

Once built-up in your arteries, plaque is difficult to remove. Cholesterol-lowering therapies may only serve to reduce further development, but not fully remedy arterial health.
The medical community also is investigating the role that different types of LDLs might play in the development of both plaque itself and the ability for plaque to remain “stable” and not break free from the arterial wall. This may be a factor even if LDL levels are low.
Low levels (below 40mg/dl) of HDL cholesterol have been shown to be a risk factor for heart diseases and high levels (above 60mg/dl) have been associated with reducing the risk of heart disease and plaque development.

Beyond cholesterol management, cardiovascular health flows from different hereditary, environmental and lifestyle factors. It is a complex equation.

The important point: cholesterol management should be thought of as a lifetime approach, starting in your teens, to maintain cardiovascular health. Like weight-management and physical fitness, cholesterol management and its nutritional tools can promote long term health.

Plant Sterols or Plant Sterol Esters: Count Correctly!

2008-03-09T16:34:00.007-04:00

Here at Kardea, we use natural plant sterol esters that combine the free plant sterol found in soy bean with a safflower oil. Sterol esters are considerably more expensive than the plant sterols, but much of the research in regard to the efficacy of sterols to consistently lower total and LDL cholesterol without adversely lowering HDL (good) cholesterol was based on the sterol ester.

The FDA first approved the sterol heart health claim only for the plant sterol ester. In this claim, the FDA defines that individuals should consume 1.3 grams/day of plant sterol esters to have a meaningful effect on heart health. To make this claim, food manufacturers are required to incorporate at least .65 grams of plant sterol esters into each serving as listed on the nutritional statement. Generally, sterol esters contain about 60% free sterols.

Since then, the FDA has allowed the claims for the free plant sterol. Under this claim, the FDA targets .8 grams of plant sterols per day with each serving containing .4 grams.

Looking beyond the FDA health claims, the National Cholesterol Education Program of the NIH, along with the American Heart Association and the American College of Cardiology, recommends daily consumption of 2 grams/day of plant sterols.

For those of us utilizing a natural and nutritional approach for cholesterol management, we must make certain that we are counting our sterol intake correctly. Kardea seeks to make this as clear as possible. We provide you with the numbers for the free sterol content in our products. For example, our bars contain 1 gram of plant sterols, and we utilize a significantly greater amount of plant sterol esters to reach this level. So, you need two bars per day to reach the NCEP recommendation.

Alternatively, a bar and two tablespoons of our sterol-fortified olive oil will achieve the same results. For recipes using Kardea olive oil with other heart healthy foods, visit www.kardeagourmet.com.

Other products might fit into your lifestyle. If you are a chip snacker, you might try the natural products at Corazonas Foods. One serving contains .4 grams of the sterols. For products containing non-natural ingredients, try Proactiv Supershots and their margerine-like spreads. Lots of other products are available.

There also are plant sterol supplements on the market. Different brands deliver different levels of sterols. Count correctly!

Red Yeast Rice Supplements-Can They Still Be Effective?

2008-02-21T10:44:00.008-05:00

FDA Consistent in Restricting Sale of Lovastatin-Natural or Synthetic

Summary: Certain types of red yeast rice naturally contain lovastatin, the same active ingredient in Merck’s prescription statin medication Mevacor. Whether natural or synthetic, the FDA has consistently maintained that lovastatin has serious potential side effects and should remain a controlled (prescription) medication. As such, the FDA denied Merck’s multiple petitions to sell low-dose Mevacor on an over-the-counter basis. The FDA also has placed restrictions on red yeast rice supplements with verified levels of the naturally-occurring statin. For those interested in natural alternatives, certain nutrients, notably plant sterols, soluble fiber from oats, barley, beans, psyllium and fruit, Omega-3’s from marine sources, niacin, and monounsaturated fats replacing saturated fats, should be considered as an effective alternative approach.

Red Yeast Rice: A Particular Type is a Natural Statin

Red yeast rice is the product of yeast grown on rice. As a food, red yeast rice can be found as a paste, whole dried grains, or as a ground powder. In these forms, it has been a common food in certain Asian diets. In its traditional forms, red yeast rice contains no more than trace amounts of the active cholesterol-lowering agent. In fact, some types of red yeast rice contain no actives.

As a supplement, a particular type of enhanced red yeast rice was shown to significantly lower total cholesterol and LDL (bad) cholesterol. The active ingredient has been identified as lovastatin, the same as found in the popular statin drug, Mevacor and its generic equivalents.

Lovastatin, in turn, is a controlled prescription medication.

Can red yeast rice supplements offer benefit in comparison with prescribed statin medications?

For those preferring naturally-derived solutions, red yeast rice sources of statins could be preferred. This conceptually would be equivalent to a naturally-derived vitamin E as opposed to a synthetic. As we have further come to understand, the active agents in a natural product may be more bioavailable or more effective due to other compounds that accompany whole food. Yet, the FDA consistently views statins--natural or synthetic-- as powerful medication with potential side-effects and potential drug interactions. As such the FDA restricts the sale lovastatin, regardless of its source.

Most recently, the FDA rejected the petition of pharmaceutical giant Merck to offer Mevacor without a prescription. Merck has made three tries to have this statin sold over the counter. In rejecting Merck’s latest petition, the FDA indicated that too many of the wrong people would use the drug if it no longer required a prescription.

Last summer, the FDA issued warnings to consumers not to buy or eat certain red yeast rice products. FDA testing revealed the products contained lovastatin.

The FDA stated that “these red yeast rice products are a threat to health because lovastatin can cause severe muscle problems leading to kidney impairment. This risk is greater in patients who take higher doses of lovastatin or who take lovastatin and other medicines that increase the risk of muscle adverse reactions. These medicines include the antidepressant nefazodone, certain antibiotics, drugs used to treat fungal infections and HIV infections, and other cholesterol-lowering medications.”

What’s in Red Yeast Rice Supplements Today?

Back in 1999, when the clinical studies on the efficacy of red yeast rice were first released, supplements with identified and controlled levels of the active compounds could be purchased. Today, however, such supplements cannot be produced. In fact, red yeast rice supplements may be made from the varieties of red yeast rice that does not the cholesterol-lowering compound. We simply do not know.

Natural Cholesterol Management Alternatives

The coupling of target levels of plant sterols (2-3g/day) and soluble fiber (10-25g/day) with a calorie-mindful diet replacing saturated and trans fats with monounsaturated fats can achieve results similar to many cholesterol-lowering medications. Niacin and omega-3s from fish oil also can play a role. Check with your health care professional about a complete program. Click Here to Learn More.

Kardea Gourmet Nutrition Bars---Now Available!

2008-02-14T15:28:00.009-05:00

Just returned from the first full production run of our gourmet nutrition bars for cholesterol management. A great experience! As many of your know, we took great care in the formulation of these bars. The criteria was to create great taste, use only all-natural ingredient, deliver effective levels of key cholesterol-managing ingredients (plant sterols, soluble fiber, soy protein), maintan a low fat, particularly low saturated fat, standards, and create a lower glycemic profile. Thanks to everyone who has been involved in this process. As we all agree, we have created a breakthrough product.

The bars will be available through our online store starting on February 25, and a limited supply of variety packs also are available (first come, first served). Single-flavor 15 counts are available in banana walnut, lemon ginger, chai spice and cranberry almond.

Thanks to all who made this start-up a huge success. I have spent a career in food manufacturing, and you folks delivered as one of the best cross-functional teams in the business.

Kardea Nutrition-enabling natural cholesterol management, heart healthy and inspired.

And our collective best wishes for Rod's grand daughter's recovery and health.

Natural Cholesterol Management-Study Reaffirms Efficacy

2008-02-12T22:19:00.012-05:00

A new study reaffirmed the recommendations of the medical community related to the power of nutrition to lower cholesterol independent of cholesterol-lowering medications.

"In the context of a low-saturated fat diet and in combination with other cholesterol-lowering dietary components, plant sterols appear to exert a very significant effect on LDL-C reduction of the order of 10 per cent for two grams per day of plant sterols," wrote lead author David Jenkins from St Michael's Hospital, Toronto."This figure is similar to studies where plant sterols have been given as the only cholesterol-lowering agent. "Numerous clinical trials in controlled settings have reported that daily consumption of 1.5 to 3 grams of phytosterols/stanols can reduce total cholesterol levels by eight to 17 per cent, representing a significant reduction in the risk of cardiovascular disease.

Participants in the new study adhered to the guidelines set out by the National Cholesterol Education Program Adult Treatment Panel III (ATP III). According to these guidelines, "therapeutic lifestyle changes" can achieve results similar to some cholesterol lowering medications. The study sought to assess the effectiveness of "each functional food component to the overall cholesterol reduction observed and whether all ingredients have to be present," explained the researchers. Jenkins and co-workers prescribed the 42 subjects (average age 63) to a diet containing viscous fibres (10 g/1,000 kcal), soy protein (22.5 g/1,000 kcal), and almonds (23 g/1,000 kcal) for 80 weeks. In addition, plant sterols were taken (one gram per 1,000 kcal), except during weeks 52 to 62.

"Increased plant sterol intakes are likely to have been a part of the ancestral human diet at about one gram per day and are part of a more plant-based diet as currently recommended for CHD risk reduction, including green leafy vegetables, raw or dry roasted nuts, and non-hydrogenated vegetable oils," wrote the authors. "Their reintroduction into the Western diet to prevent CHD may be seen as similar to the desire to reintroduce fibre into the diet to reduce the risk of a number of chronic diseases....Plant sterols therefore appear a good fit with other cholesterol-lowering components in a dietary portfolio to reduce CHD risk," they concluded.

D Jenkins et al. Effect of plant sterols in combination with other cholesterol-lowering foods.
Metabolism, Volume 57, Issue 1, Pages 130-139

Sources of Good Fats for Natural Cholesterol Management

2008-02-04T13:17:00.001-05:00

Natural cholesterol managers seek to obtain 25-35% of their calories from fats, striving for zero trans fats, less than 7% from saturated fats, and no more than 10% and 20% of their calories from polyunsaturated and monounsaturated fats respectively. We have extolled the virtures of extra-virgin olive oil , but many people are asking us for more information on the levels of these fatty acids in the products they consume. Here is a good chart from the Harvard School of Public Health:

And if you are looking to build a framework for natural cholesterol managementt, consider our extra-virgin olive oil with added plant sterols (.5g plant sterols from plant sterol esters).

Vegans & High Cholesterol

2008-01-30T09:52:00.001-05:00

Free of all animal products, a strict vegan diet contains no cholesterol. Yet, a vegan may face elevated levels of cholesterol. A paradox? Not really. We all are highly effective at producing and recycling cholesterol. Each cell wall requires cholesterol. Cholesterol serves as a building block for important hormones. Cholesterol plays a role in the digestion of dietary fats. We can manufacture cholesterol at a cellular level. We produce cholesterol in our livers. For many Americans, their own body produces 70%-80% of the cholesterol found in the blood stream. Only the residual comes from foods.

Within the context of our modern lifestyles and extended life spans, our well developed ability to manufacture cholesterol can adversely affect our heart and vascular health. This is true for vegans, vegetarians and omnivores alike.

If you are a vegan, how should you think about your cholesterol levels? Start with the facts. Get a blood test that provides information on your total cholesterol and its components—LDL (bad) cholesterol, HDL (good) cholesterol and triglycerides. Then factor in your own family history to frame your understanding of these numbers. Then consider that a health circulatory system can play an important role in your long term health and wellness.

Other Benefits of a Vegan Diet

In terms of cholesterol management, vegans often enjoy benefits other than restricted intake of dietary cholesterol. The diet may be lower in saturated fats. Research shows that these fats, particularly those from animal and dairy products, elevate cholesterol levels. Interestingly, certain saturated fats from plants have been shown to be cholesterol neutral.

Vegans and vegetarians also consume a higher level of plant sterols. Plant sterols are the plant kingdom’s equivalent of cholesterol. At 2 grams per day, these sterols have been shown to lower LDL blood cholesterol levels by 15% or more. Omnivores typically consume 250mg (.25g) per day, while vegetarians consume between 400mg and 750mg.

Other Nutritional Measures for Cholesterol Management

If you are a vegan and still face issues related to your cholesterol levels, you can consider other measures consistent with your philosophy and commitment. Utilize high monounsaturated oil, like extra –virgin olive oil, in place of other oils and fats, search out plant sterol fortified foods, and increase your intake of cholesterol-lowering soluble fiber from oats, barley, beans, psyllium and fruit. For additional resources on Natural Cholesterol Management , click on to the Kardea Nutrition website.

Is Your Doctor Doubtful? Developing a Partnership with Your Health Providers

2008-01-24T17:08:00.000-05:00

O.K. you have done your homework, and you are convinced that natural cholesterol management can and should be a meaningful part of your personal approach to long term health and longevity.

But you want to engage your doctor in setting up a system to monitor your progress. You know you need to monitor what is working and what is not. This will require periodic blood tests prescribed by your doctor and hopefully paid for by your health insurance.

But you are concerned that your doctor will be dismissive of your desired course of action.

No doubt, some physicians are more knowledgeable than others about natural nutritional approaches to cholesterol management. But most physicians, when presented with the evidence, are willing to explore the options.

So, if you meet resistence, suggest that your doctor read the recommendation of the NIH's National Cholesterol Education Program most recent report of the effecteness of "therapeutic lifestyle changes." In the NCEP recommendations, it is noted that this approach can achieve results similar to that attained by cholesterol lowering medication.

The NCEP reports, plus a listing of related research and studies, can be found on the Kardea Nutrition website.

Your doctor's views about natural cholesterol management also may hinge on concerns about compliance. Many doctors routinely recommended the therapeutic lifestyle changes, but patents often have difficulty changing their habits. It is on this point that you need to be honest with yourself. Can you maintain --- on a daily basis--the steps necessary to be effective with natural cholesterol management.

Sometime this is not easy. I know. I have been working on it. I designed the Kardea Nutrition products to make it easier for me to maintain the program and achieve measurable and signficant improvements in my blood lipid levels.

Give us a holler and let know how you are developing your relationships with your health care provider. Others will find your experience and advice really helpful!

2008-01-23T21:22:00.000-05:00

So Now I Know What Menopause Feels Like

I was at a reception tonight celebrating the first anniversary of the Connecticut Center for Entrepreneurship and Innovation. I used some of the services of this Center in launching Kardea Nutrition.

As a leading Kardea missionary, I found myself in discussions with a couple in their 60's working to manage their cholesterol levels through natural means. They had some misconceptions, but they had many elements of the program down, including the use of niacin. We got to sharing our experiences of the flushing effect of this essential B vitamin. The wife looked me straight in the eye, and said "you've got to admit, it feels like menopause all over again."

Well, my wife tells me that launching Kardea Nutrition may be my manifestation of male menopause, but I think for the male, menopause is largely an emotional passage. In any event, I am grateful for the insight.

So guys, if you also want to be able to relate better to your spouse during a hot flash, try some niacin. Separately, I have learned not only to tolerate the niacin flush, but also to appreciate the sensation....and the science supporting niacin's role as part of a broader program for natural cholesterol management is impressive and extensive.

For an overview of natural cholesterol management, join us at http://www.kardeanutrition.com/cholesterol/index.aspx. You also can search on this site to find selected information and articles related to niacin.

Cumin Spiced Black Beans-Quick & Delicious

2008-01-22T21:45:00.001-05:00

A great pleasure in the culinary arts is stumbling on an incredibly easy, quick and flavorful recipe. I can devote hours to the preparation of some dishes only to receive praise for a five minute side. Everything may taste great, but sometimes these easy dishes find their way to top honors. A spiced black bean salad falls into this category.

Spiced Black Bean Salad

How to Make
Ingredients
16 ounce Canned Black Beans
2 -3 Tablespoons White Distilled Vinegar
1/3 Cup Green Olives-Pitted & Chopped(with or without pimentos)
2 Tablespoons Extra Virgin Olive Oil fortified with Plant Sterols
3-4 Tablespoons Chopped Onion or Scallion
1/8-1/4 Teaspoon Cumin
Hot Sauce to Taste

Rinse beans until water flows clear and drain. This freshens the canned beans and provides a more natural flavor. It also reduces the amount of salt added by the manufacturer. Add all the other ingredients. It best if you let this marinate for about an hour or two, but it can be served immediately.

Depending on the availability of fresh produce, you can build this into a main dish that’s great for a summer lunch. Add cucumber, tomato, zucchini, radish, apple, pear.... let me know what's working.

Spiced Black Beans & Natural Cholesterol Management

As we have emphasized, natural cholesterol management (NCM) targets a daily intake of 10-25g of soluble fiber, 2-3g of plant sterols and at least 500mgs of Omega-3 fatty acids from marine sources. You also want to replace saturated fats with monounsaturated fats. Collectively, these nutrients can drop your LDL cholesterol by 30%.

For a 5 ounce serving, this spiced black bean salad delivers 2g soluble fiber and .25g of plant sterols. Utilizing only olive, this dish is high in monounsaturated fats and saturated fats are held to 5.6% of total calories, less than the 7% recommended by the National Cholesterol Education Program. (see chart above for % of therapeutic levels achieved with a single serving)

The spice black beans also complement a tumeric barley pilaf (see barley pilaf blog for recipe and NCM nutrient levels). To round out this meal, serve with a grilled chicken with a raisin port reduction (blog post coming).

Kardea Nutrition's Natural Bars for Cholesterol Management

2008-01-21T14:16:00.000-05:00

O.K. I have gone off on a policy & political tangent over the past view days. I do think that the events and debates of last week regarding cholesterol medications required that I chime in.

Focusing back to the core goal of Kardea: to develop nutritional tools that enable natural cholesterol management. As a formulation standard we look to multiple product attributes: delicious, convenient, natural, calorie-mindful and therapeutic.

To optimize these attributes, I started looking at those foods that I am likely to eat everyday. If I was already eating, I was likely to keep eating it. If I wasn't already eating, I did not want to add a new source of calories. The trick was how to keep it something I crave while being effective, being therapeutic.

The nutritional bars were a really convenient place to start. Before founding Kardea, I had spent the last 12 years of my life running a specialty chocolate company. I had developed a habit--a craving--for a daily piece piece of dark chocolate (with a late morning cup of coffee--this has to be one of nature's great taste combinations!).

Certainly, dark chocolate is getting good reviews for its cardiovascular benefits. I certainly have tracked this, and discussed it with some people over at the Yale Medical School. This science seems promising, but I am not sure I would yet incorporate chocolate into my program for natural cholesterol management. Instead, I looked to develop a substitute for my morning craving. The Kardea bars achieved this goal, and then some.

First off, I think these bars really are tasty. All natural ingredients such as almond butter, authentic spices like nutmeg, clove or cardamom, real fruit and full flavors.

These bars also provide meaningful levels of plant sterols (1 full gram), fiber (7 grams; 3 grams of heart hearthy soluble fiber) and protein (7 grams total and close to 4 grams of soy protein). The FDA has endorsed these nutrients for their ability to help improve blood lipid profiles including a lowering of LDL (bad) cholesterol.

While only 150 calories each, these bars are more satisfying that the morning chocolate fix. I suspect this is a tribute to the protein and fiber levels.

Further, the bars are sweentened with lower glycemic agave syrup and brown rice syrup. Couple these with the fibers which slow glucose uptake, and I feel that I evened out the sugar spike. So by lunch, I no longer have the urge to eat too fast and too much.

The whole family has been eating the samples through the development process. We all ---friends and family--really enjoy them. Our first production run is now scheduled for mid-February, and they will be available to ship at the end of this month.

To get a product availability alert with an introductory 25% coupon, sign up for our newletter, UpBeat. http://visitor.constantcontact.com/email.jsp?m=1101913937814&p=oi

For additional product information: http://shop.kardeanutrition.com/merchant.mvc?Screen=SFNT&Store_Code=KNFNCM

The Cholesterol "Pill" & Health Policy

2008-01-18T15:00:00.000-05:00

Over the past few days, the media has meted out criticisms of Big Pharma and their cholesterol medications. Certainly, some of it is well deserved. Some, however, confuses the issues and does not consider some fundamental issues related to health policy.

A Bit of Background

Statins and other cholesterol medications represent a critical piece of Pharma's profits. Worldwide, cholesterol meds represent the single largest class of drugs sold--exceeding $25 billion per year.

Why so much?

These medications do work to reduce LDL (bad) cholesterol, and the relationship between LDL cholesterol, heart disease and stroke has been well study and confirmed.

Then there is the magnitude of the issue. Combined, cardiovascular diseases are the primary causes of death and morbidity in the United States.

But, these medication do not "heal". Stop taking these medications, and your LDL cholesterol will rise--all other things being equal. Users of cholesterol medications thus may find themselves on these drugs for decades.

Overall, couple the huge population at risk of cardiovascular disease with the length of time that these medications are potential used, and a huge market is created.

An Oversold Solution?

Cholesterol medications have been oversold and hyped in their ability to remedy heart issues.

Managing cholesterol can improve the cardiovascular system, but it is not and cannot be a guarantee of heart health. Cholesterol also can be managed by means other than medications--nutrition, weight control and exercise. Nutritional approaches that combine nutrients that actively and positively influence blood lipids ---Omega-3 & monounsaturated fatty acids in lieu of saturated fats, plant sterols, soluble fiber, niacin---can achieve results equivalent to many of medications, particularly for the borderline line high cholesterol types like me. This view is widely endorsed in the medical community including the American Heart Association and the American College of Cardiologists.

Certainly, this does not mean that these drugs are without value. For many, the lifestyle and nutritional approaches are not adequate. Medications is required, and for those at high short term risk, they may be essential. Yet, theses meds should complement the therapeutic lifestyles. The approaches should be integrated and the medications should not be the first line of therapeuty.

Moreover, these medications are most effective in affecting only a component of cholesterol---lowering LDL cholesterol. There are other aspects of blood lipids that are important for heart health---the level of HDLs, the ratio of total cholesterol to HDLs, the size of the LDL particle--to name just a few.

Even in regard to LDL cholesterol, a single medication may not achieve heart risk adjusted targets (to calculate your risk-adjusted ldl targets, go to http://www.kardeanutrition.com/cholesterol/ldl_calculator.aspx ). The pharmaceutical solution is to identify other drugs to be taken with the existing medications.

No doubt, new drugs are coming to market or are in development that work with existing medications to favorably affect blood lipid levels. So, you can look forward to taking more medications! Today, we find ourselves with many people taking many drugs, and overall, we are only dimly aware of their interactions and long term afffects on health.

Drivers of a Healthcare Imbalance

From a health policy perspective, we need to give careful thought to what is going.

One issue is that we allow Big Pharma to spend hundreds of millions dollars per year promoting these medications. At whose expense? Well for one, the consumer advertising campaigns dwarf the public health education campaigns that advance nutritional and lifestyle alternatives. We all would be well served if the consumer received more balance input.

A few policy alternatives could be considered. We could require the pharmaceutical companies to contribute an equivalent amount of advertising money to lifestyle and nutrition public health education. This would not be unlike the tobacco companies funding of smoking cessation programs. Alternatively, we could require those media outlets that air these promotion to donate airtime to publilc health education.

Consumer behavior and incentives also are at issue. The advertising ---this unnecessary hype- works in large part because many consumers want to believe that a single pill will eliminate the risk of heart disease--regardless of what they eat, how much they weigh or how much exercise they get. Intellectually, not many of us would ever concede that we believe in the power of the single pill. Practically, the single pill gives us comfort when we fail to live heart healthy lifestyles.

At least for the well-insured consumer, it also may be cheaper, both in terms of time and money, to pursue the pharmaceutical approach than to embrace the alternatives.

Presidential candidates from both parties are discussing fundamental changes in our health care system. Special interest, including Big Pharma, can be expected to mold this system to their benefit. As citizen, we will be best served by making sure that real public health is advanced. Make your voice heard in this debate!

"Cholesterol Drug Bombs"-New York Times Editorial Misses Opportunity

2008-01-16T15:58:00.000-05:00

Yesterday, the New York Times editorial board wrote "there have long been suspicions, but it was still very disturbing to learn this week that a heavily promoted cholesterol-lowering drug had flunked a clinical trial of its effectiveness in reducing fatty deposits in arteries....The drug, Zetia, and a combination pill that contains it, Vytorin...generated more than $5 billion in sales last year."

You probably know the ads for Vytorin. They have run on T.V., in magazines and on-line. They certainly are clever, creative and very expensive. According to Nielsen Monitor-Plus, in 2006 the companies spent $136.3 million to advertise Vytorin and $115 million from January to October of 2007.

Vytorin combines Zocor, a statin produced by Merck (and also marketed by generic drug manufactures and sold at lower prices) with the Schering-Plough's Zetia. Statins work by reducing the production of cholesterol in the liver. Zetia works to reduce the absorption of dietary and liver-produced cholesterol from the intestines into the blood stream.

The study compared the effects of treating patients with Vytorin, the combination drug, with a statin alone. The patients all had abnormally high LDL cholesterol. In the study, LDL cholesterol was reduced more significantly by Vytorin than with the statin alone. These results are consistent with the results of a number of other studies.

It also was hypothesized that the added cholesterol-lowering effect of Vytorin would lead to a more significant reduction of arterial plaque growth. This relationship did not hold. The lower cholesterol achieved by the Vytorin did not yield a reduction in plaque build-up as compared to the statin only. In fact, the Vytorin group was found to have a more rapid development of plaque than the statin-only group.

The Times reports that these companies had been “cynically sitting on the results for more than a year” while spending hundreds of millions of dollars to convince consumers that the Vytorin is a preferred cholesterol drug. This certainly is a very legitimate criticism.

The Times continued that "the findings also raise doubts about the current belief that lowering cholesterol is the key to cardiovascular health. The study showed that Vytorin reduced bad cholesterol significantly more than Zocor alone. The problem was that it failed to reduce the formation of plaque."

And here is perhaps were the Times should have been somewhat more careful. This study now represents a single set of data among a sea of data that concludes lower LDL cholesterol lowers the risks of heart attacks and strokes. Numerous studies also indicate that LDL cholesterol above 100mg/dl will lead to the development of arterial plaque.

Instead of casting doubt on the general wisdom of cholesterol management, the Times would have served the public well by offseting the barrage of pharmaceutical advertising and reinforce the well-documented science regarding natural alternatives to cholesterol management. An extensive NIH report (http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.htm), for instance, concludes that the "amount of LDL reduction from Therapeutic Lifestyle Changes compares well with many of the cholesterol-lowering drugs." Among the recommendations are the consumption of certain positive nutrients such as plant sterols, soluble fibers, monounsaturated fats in place of saturated and trans fats, and Omega-3s. Needless to say, weight management and exercise is part of the NIH recommendations.

For more information on natural cholesterol management nutritients: http://www.kardeanutrition.com/cholesterol/program.aspx

Soluble Fiber--From Hype to Health

2008-01-06T17:47:00.001-05:00

Take a walk through the grocery aisle, and you will quickly find many products claiming to be heart healthy.

For many of these products, the heart healthy claims flows from two essential nutritional characteristics. They are low in saturated and trans fats, and they deliver levels of soluble fiber sufficient to meet certain FDA-allowed heart health claims. To make these claims, the FDA requires that the products deliver in each serving at least .75 grams of soluble fiber from oats or barley, or 1.7 grams of soluble fiber from psyllium.

For those of us seeking measurable improvements in our cholesterol levels, success requires consuming substantially greater levels of soluble fiber. The National Cholesterol Education Program of the National Institutes of Health recommends 10-25 grams per day. Depending on your chemistry, consumption at these levels can lower LDL cholesterol by up to 8-10%. Some studies have suggested that results could be more significant.

How much oatmeal is required to reach 10 grams of soluble fiber? Roughly 5 servings, or about 2 lbs of prepared oatmeal. For 25 grams, you would need to consume about 5 lbs of prepared oatmeal, or about 2000 calories per day from oatmeal. Nay!

While oats certainly are a good starting point, I begin the day with a heaping tablespoon (=3 teaspoons) of whole psyllium husk. Psyllium seed husks are nature's most concentrated source of cholesterol-lowering soluble fiber. Where oats are only about 5% soluble fiber, psyllium husks are about 60%. With a tablespoon of psyllium husk, I start the day with 9 grams of soluble fiber (note: start with a teaspoon and work your way up).

5-6 servings of fruits and vegetables through the course of the day gets me another 5-6 grams.

From here, I shoot for the upper levels of the cholesterol-lowering soluble fiber targets. Success typically requires some culinary creativity and an understanding of the sources of soluble fiber.

Here is one recipe that you may find a useful addition to your weekly food choices:

Barley Pilaf
4 Servings of About 1 Cup Each

Barley never came to my mind as something I would crave. Yet, I discovered that barley stands side-by-side with oats as an FDA-endorsed food for promoting heart health by lowering cholesterol. I have since set out to explore how barley could be enjoyed in something other than a malted beverage.

As it turns out, a barley pilaf can be a delicious alternative to the rice, potato or pasta “starch” in protein/starch/vegetable triad my mom insists constitutes a meal.

A pilaf can be cooked to complement any number of dishes. Adapt by incorporating any number of spices. Start with the basic pilaf and create from there.

So, you ask "why don't more people eat barley." Part of the answer lies with the fact that cooking barley can be a bit tricky. If you're not careful, you might find your pilaf with hot cereal qualities---perhaps great for a cold morning but not the best for a dinner. But if you take a bit of care, you barley pilaf can be a great nutritious alternative to high glycemic, low fiber carbs.

Ingredients
1 Cup Rinsed Pearled Barley
2 Cups Water
1 Small Onion-Finely Chopped
2 Tablespoons Extra Virgin Olive Oil (preferably fortified with plant sterols)*
½ Teaspoon Turmeric
Salt & Pepper to Taste

*to double-up on the cholesterol lowering abilities of this dish, I formulated an extra-virgin olive oil with added plant sterols. This olive oil is available through the Kardea Nutrition website
http://www.kardeanutrition.com/products/food.aspx . If you want to reduce total fat, cut recipe to 1 tablespoon of oil.

Direction
Heat a sauce pan over medium heat. When pan is hot, add olive oil and chopped onion. Saute for a few minutes. Add rinsed pearl barley and saute for 5 or so minutes, stirring regularly and making sure that barley does not burn or stick to bottom of pan. Add turmeric and then water to the hot barley and stir. Cover, lower heat and cook until tender but still a bit chewy (30 minutes). Remove cover and on very low heat, let steam escape. Periodically fluff to prevent sticking to bottom of pan. Serve when barley appears about the consistency of steamed rice. This all may sound a bit cumbersome, but it works. The turmeric also give the barley a beautiful yellow color, accenting the visual appeal of an entire meal.

Nutritional Facts
(about a cup of cooked barley pilaf)
Calorie: 240 Calories from Fat: 70
Total Fat: 8g from olive oil; monounsaturated: 5.7g; polyunsaturate fat: 1.15g; saturated fat: 1.15g (4.3% of total calories); Trans fat: 0.0g.
Cholesterol: 0.0
Total Carbohydrates: 40g; Total Fiber: 8g; Soluble Fiber: 2g.
Protein: 5g.
Plant Sterol: .25g

Stepping-Up
You can try adding any number of spices. Try curry or cumin when serving lean meats or roasted root vegetables. Try ginger and currents when serving fish. Serve with a kidney bean chili or black bean salad (recipe in next blog) to create a meal that delivers 3-4g of soluble fiber.

Do You Have A Great Barley Recipe? Can you improve this recipe? Post your thoughts and recipes to this blog to share with the Kardea community.

Natural Cholesterol Management - Numbers are In

2007-12-22T15:26:00.000-05:00

In a four month period, I naturally lowered my LDL (bad) cholesterol from 161mg/dl to 131mg/dl (about 19% improvement), increased my HDL (good) cholesterol from 55 to 61 (about a 10% improvement). Total cholesterol was reduced from from 228 (it had been as high as 239) to 201. I am not yet at the "under 200" target, but with my relatively high HDLs and declining LDLs, I was now closing in on some desireable cholesterol levels.

I achieved these goals with a less-than-disciplined, natural approach combining plant sterols, viscous soluble fiber and low levels of immediate release niacin from nicotinic acid.

I always have eaten fairly well. Low in terms of red meat and dairy, low in terms of saturated fats, processed foods and dietary cholesterol. Mediterranean cuisine also has long been a personal preference, and I use olive oil (and occassionally canola oil) in all cooking and food prep. I also eat a fair amount of vegetables and whole grains, and lots of fruit.

My internist had suggested that I might need to consider the use of a medication to achieve better cholesterol levels. As an otherwise healthy 49 male, I was not ready to start a lifetime of medication to create healthier cholesterol levels. I began a search for the alternatives, and found that a number of nutrients ---viscous soluble fibers, plant sterols, niacin and Omega-3 fatty acids --- can collectively enable an individual to substantially improve one's blood lipid profiles.

So, I began developing a personal program that incorporates these nutrients in foods and supplements. More importantly, I was looking to enjoy these foods (food and cooking are my pre-occupation and a source of daily joy). With my somewhat less-than-disciplined approach to consuming soluble fiber, plant sterols and niacin, I achieved the results noted above.

Note on full disclosure: While I weigh about the same amount, I did increase the frequency of exercise from 2 to 4 days per week. My workout intensity also increased.

I am now looking to refine my approach to further improve my blood lipid levels. As someone with year's of experience in the natural and gourmet foods, I also decided to create Kardea Nutrition to develop products that comfortably fit into my daily eating habits (and hopefully yours!). I also do not want these foods to lead to an increase in the total level of calories I take in each day.

My first set of products should be available in early February, but early in Janary, you will be able to log onto my website to see what's coming (http://www.kardeanutrition.com/).

Overall, I am sincerely interested in networking with others that are attempting to manage cholesterol levels naturally. Let's share what is working.....and based in part on these exchanges, I will be developing other foods and supplements that strive to meet the combined goals of delicious, natural, calorie-mindful and effective in terms of natural cholesterol management.